ENZYME entry: EC 2.4.1.68

Accepted Name
Glycoprotein 6-alpha-L-fucosyltransferase.
Alternative Name(s)
GDP-fucose--glycoprotein fucosyltransferase.
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase.
GDP-L-fucose-glycoprotein fucosyltransferase.
Glycoprotein fucosyltransferase.
Guanosine diphosphofucose-glycoprotein fucosyltransferase.
Reaction catalysed
GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine <=> GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine
Comment(s)
Catalyzes a reaction similar to that of EC 2.4.1.214, but transfers the L-fucosyl group from GDP-beta-L-fucose to form an alpha-1,6- linkage rather than an alpha-1,3-linkage.
Cross-references
BRENDA2.4.1.68
EC2PDB2.4.1.68
ExplorEnz2.4.1.68
PRIAM enzyme-specific profiles2.4.1.68
KEGG Ligand Database for Enzyme Nomenclature2.4.1.68
IUBMB Enzyme Nomenclature2.4.1.68
IntEnz2.4.1.68
MEDLINEFind literature relating to 2.4.1.68
MetaCyc2.4.1.68
UniProtKB/Swiss-Prot
Q9N0W2, FUT8_BOVIN;  Q659X0, FUT8_CANFA;  Q9VYV5, FUT8_DROME;  
Q9BYC5, FUT8_HUMAN;  Q9WTS2, FUT8_MOUSE;  Q6EV77, FUT8_PANTR;  
P79282, FUT8_PIG;  Q5NVB3, FUT8_PONAB;  Q6EV76, FUT8_RAT;  
Q6NVP8, FUT8_XENTR;  

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