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ENZYME entry: EC 18.104.22.168
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|Heparan glucuronyltransferase II.|
|UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan <=> UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan|
- Involved in the biosynthesis of heparin and heparan sulfate.
- Some forms of the human enzyme (particularly the enzyme complex
encoded by the EXT1 and EXT2 genes) act as bifunctional
glycosyltransferases, which also have the EC 22.214.171.124 activity
required for the synthesis of the heparan sulfate disaccharide
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
|Q5IGR8, EXT1A_DANRE; ||Q5IGR7, EXT1B_DANRE; ||Q5IGR6, EXT1C_DANRE; |
|A5D7I4, EXT1_BOVIN; ||Q9JK82, EXT1_CRIGR; ||Q9V730, EXT1_DROME; |
|Q16394, EXT1_HUMAN; ||P97464, EXT1_MOUSE; ||A9X1C8, EXT1_PAPAN; |
|Q5RBC3, EXT1_PONAB; ||O77783, EXT2_BOVIN; ||O01705, EXT2_CAEEL; |
|Q9Y169, EXT2_DROME; ||Q93063, EXT2_HUMAN; ||P70428, EXT2_MOUSE; |
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