Due to improvement work scheduled on this server, some services may not be fully operational on Tuesday December 12 daytime (CEST).
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.4.1.225

Accepted Name
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase.
Alternative Name(s)
Heparan glucuronyltransferase II.
N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase.
Reaction catalysed
UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan <=> UDP + beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
Comment(s)
  • Involved in the biosynthesis of heparin and heparan sulfate.
  • Some forms of the human enzyme (particularly the enzyme complex encoded by the EXT1 and EXT2 genes) act as bifunctional glycosyltransferases, which also have the EC 2.4.1.244 activity required for the synthesis of the heparan sulfate disaccharide repeats.
Cross-references
BRENDA2.4.1.225
EC2PDB2.4.1.225
ExplorEnz2.4.1.225
PRIAM enzyme-specific profiles2.4.1.225
KEGG Ligand Database for Enzyme Nomenclature2.4.1.225
IUBMB Enzyme Nomenclature2.4.1.225
IntEnz2.4.1.225
MEDLINEFind literature relating to 2.4.1.225
MetaCyc2.4.1.225
UniProtKB/Swiss-Prot
Q5IGR8, EXT1A_DANRE;  Q5IGR7, EXT1B_DANRE;  Q5IGR6, EXT1C_DANRE;  
A5D7I4, EXT1_BOVIN;  Q9JK82, EXT1_CRIGR;  Q9V730, EXT1_DROME;  
Q16394, EXT1_HUMAN;  P97464, EXT1_MOUSE;  A9X1C8, EXT1_PAPAN;  
Q5RBC3, EXT1_PONAB;  O77783, EXT2_BOVIN;  O01705, EXT2_CAEEL;  
Q9Y169, EXT2_DROME;  Q93063, EXT2_HUMAN;  P70428, EXT2_MOUSE;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-