ENZYME entry: EC 2.4.2.31

Accepted Name
NAD(+)--protein-arginine ADP-ribosyltransferase.
Alternative Name(s)
ADP-ribosyltransferase.
Mono(ADP-ribosyl)transferase.
Mono-ADP-ribosyltransferase.
NAD(P)(+)--arginine ADP-ribosyltransferase.
NAD(P)(+)--protein-arginine ADP-ribosyltransferase.
Reaction catalysed
  • NAD(+) + protein-L-arginine <=> nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine
  • NADP(+) + protein-L-arginine <=> nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine
Comment(s)
  • Arginine residues in proteins act as acceptors.
  • Free arginine, agmatine ((4-aminobutyl)guanidine), arginine methyl ester and guanidine can also do so.
  • Catalyzes the NAD(+)-dependent activation of EC 4.6.1.1.
  • Some bacterial enterotoxins possess similar enzymatic activities (cf. EC 2.4.2.36).
Cross-references
PROSITEPDOC00993
BRENDA2.4.2.31
EC2PDB2.4.2.31
ExplorEnz2.4.2.31
PRIAM enzyme-specific profiles2.4.2.31
KEGG Ligand Database for Enzyme Nomenclature2.4.2.31
IUBMB Enzyme Nomenclature2.4.2.31
IntEnz2.4.2.31
MEDLINEFind literature relating to 2.4.2.31
MetaCyc2.4.2.31
UniProtKB/Swiss-Prot
A2PU44, CHELT_VIBCL;  Q838U8, EFV_ENTFA;  A0QLI5, MAV_MYCA1;  
P52961, NAR1_HUMAN;  Q60935, NAR1_MOUSE;  Q03515, NAR1_RABIT;  
P17981, NAR2A_MOUSE;  P17982, NAR2A_RAT;  O35975, NAR2B_MOUSE;  
P20974, NAR2B_RAT;  Q13508, NAR3_HUMAN;  Q8R2G4, NAR3_MOUSE;  
Q93070, NAR4_HUMAN;  Q9CRA0, NAR4_MOUSE;  Q95NE0, NAR4_PANTR;  
Q0VC22, NAR5_BOVIN;  Q96L15, NAR5_HUMAN;  P70352, NAR5_MOUSE;  
Q5XHY4, NAR5_RAT;  Q92080, NARE_CHICK;  P55806, NRT1_CHICK;  
P55807, NRT2_CHICK;  Q8N5Y8, PAR16_HUMAN;  Q7TMM8, PAR16_MOUSE;  
Q7N8B1, PHXA_PHOLL;  P17450, SPVB_SALCH;  P24419, SPVB_SALDU;  
P55220, SPVB_SALEN;  D0ZHS9, SPVB_SALT1;  P21454, SPVB_SALTM;  
A3UNN4, VIS_VIBSP;  

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