ENZYME entry: EC 2.4.2.36

Accepted Name
NAD(+)--diphthamide ADP-ribosyltransferase.
Alternative Name(s)
ADP-ribosyltransferase.
Mono(ADP-ribosyl)transferase.
Reaction catalysed
NAD(+) + peptide diphthamide <=> nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide
Comment(s)
  • Diphtheria toxin and some other bacterial toxins catalyze this reaction.
  • The acceptor is a diphthamide residue in elongation factor 2 (cf. EC 2.4.2.31).
Cross-references
BRENDA2.4.2.36
EC2PDB2.4.2.36
ExplorEnz2.4.2.36
PRIAM enzyme-specific profiles2.4.2.36
KEGG Ligand Database for Enzyme Nomenclature2.4.2.36
IUBMB Enzyme Nomenclature2.4.2.36
IntEnz2.4.2.36
MEDLINEFind literature relating to 2.4.2.36
MetaCyc2.4.2.36
UniProtKB/Swiss-Prot
P01555, CHTA_VIBCH;  Q5EK40, CHXA_VIBCL;  P00588, DTX_CORBE;  
P00587, DTX_COROM;  P11439, TOXA_PSEAE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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