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ENZYME entry: EC 2.5.1.108

Accepted Name
2-(3-amino-3-carboxypropyl)histidine synthase.
Reaction catalysed
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
Cofactor(s)
Iron-sulfur.
Comment(s)
  • Modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical.
  • The enzyme is present in archae and eukaryotes but not in eubacteria.
  • Part of diphthamide biosynthesis.
  • Formerly EC 2.5.1.n7.
Cross-references
BRENDA2.5.1.108
EC2PDB2.5.1.108
ExplorEnz2.5.1.108
PRIAM enzyme-specific profiles2.5.1.108
KEGG Ligand Database for Enzyme Nomenclature2.5.1.108
IUBMB Enzyme Nomenclature2.5.1.108
IntEnz2.5.1.108
MEDLINEFind literature relating to 2.5.1.108
MetaCyc2.5.1.108
UniProtKB/Swiss-Prot
Q57907, DPH2_METJA;  O58832, DPH2_PYRHO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-