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ENZYME entry: EC 2.5.1.115

Accepted Name
Homogentisate phytyltransferase.
Alternative Name(s)
HPT.
Reaction catalysed
Phytyl diphosphate + homogentisate <=> diphosphate + 2-methyl-6-phytylbenzene-1,4-diol + CO(2)
Cofactor(s)
Mg(2+).
Comment(s)
  • Involved in the biosynthesis of the vitamin E tocopherols.
  • While the enzyme from the cyanobacterium Synechocystis PCC 6803 has an appreciable activity with geranylgeranyl diphosphate (EC 2.5.1.116), the enzyme from the plant Arabidopsis thaliana has only a low activity with that substrate.
  • Formerly EC 2.5.1.n8.
Cross-references
BRENDA2.5.1.115
EC2PDB2.5.1.115
ExplorEnz2.5.1.115
PRIAM enzyme-specific profiles2.5.1.115
KEGG Ligand Database for Enzyme Nomenclature2.5.1.115
IUBMB Enzyme Nomenclature2.5.1.115
IntEnz2.5.1.115
MEDLINEFind literature relating to 2.5.1.115
MetaCyc2.5.1.115
UniProtKB/Swiss-Prot
P73726, HGGT_SYNY3;  Q8VWJ1, HPT1_ARATH;  B7FA90, HPT1_ORYSJ;  
Q0D576, HPT2_ORYSJ;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-