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ENZYME

ENZYME entry: EC 2.5.1.3

Accepted Name
thiamine phosphate synthase
Alternative Name(s)
thiamine-phosphate diphosphorylase
thiamine-phosphate pyrophosphorylase
thiamine-phosphate synthase
TMP diphosphorylase
TMP pyrophosphorylase
Reaction catalysed
  • 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate
  • 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) <=> CO2 + diphosphate + thiamine phosphate
  • 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) <=> diphosphate + thiamine phosphate
Comment(s)
  • The enzyme catalyzes the penultimate reaction in thiamine de novo biosynthesis, condensing the pyrimidine and thiazole components.
  • The enzyme is thought to accept the product of EC 2.8.1.10 as its substrate.
  • However, it has been shown that in some bacteria, such as Bacillus subtilis, an additional enzyme, EC 5.3.99.10 converts that compound into its tautomer 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate, and that it is the latter that serves as the substrate for the synthase.
  • In addition to this activity, the enzyme participates in a salvage pathway, acting on 4-methyl-5-(2-phosphono-oxyethyl)thiazole, which is produced from thiamine degradation products.
  • In yeast this activity is found in a bifunctional enzyme and in the plant Arabidopsis thaliana the activity is part of a trifunctional enzyme.
Cross-references
BRENDA2.5.1.3
EC2PDB2.5.1.3
ExplorEnz2.5.1.3
PRIAM enzyme-specific profiles2.5.1.3
KEGG Ligand Database for Enzyme Nomenclature2.5.1.3
IUBMB Enzyme Nomenclature2.5.1.3
IntEnz2.5.1.3
MEDLINEFind literature relating to 2.5.1.3
MetaCyc2.5.1.3
Rhea expert-curated reactions2.5.1.3
UniProtKB/Swiss-Prot
P40386, THI6_SCHPOP41835, THI6_YEASTQ57688, THIDN_METJA
Q9WZP7, THIDN_THEMAO66833, THIE1_AQUAEQ97RS5, THIE1_STRPN
Q8DQK4, THIE1_STRR6O67378, THIE2_AQUAEP66920, THIE2_STRPN
P66921, THIE2_STRR6Q8G7X1, THIEC_BIFLOQ8FTH8, THIED_COREF
Q8NQH1, THIED_CORGLP61422, THIED_GEOSLA0LTK3, THIE_ACIC1
B7JBI2, THIE_ACIF2B5ERP0, THIE_ACIF5B3GX82, THIE_ACTP7
A6VPG9, THIE_ACTSZQ8UAS8, THIE_AGRFCQ21VL5, THIE_ALBFT
Q0VSP5, THIE_ALCBSA6TMN5, THIE_ALKMQA8MK92, THIE_ALKOO
Q2IM25, THIE_ANADEB7GKQ8, THIE_ANOFWO28205, THIE_ARCFU
Q5P6J5, THIE_AROAEA0JYP1, THIE_ARTS2A8IGE6, THIE_AZOC5
A1KB60, THIE_AZOSBC1DMY6, THIE_AZOVDC3PBW1, THIE_BACAA
C3L627, THIE_BACACA0R981, THIE_BACAHQ81Z95, THIE_BACAN
B7JN72, THIE_BACC0P61410, THIE_BACC1C1EVE6, THIE_BACC3
B7H7H5, THIE_BACC4B7HT70, THIE_BACC7A7GKR4, THIE_BACCN
B9J2L5, THIE_BACCQQ81IG8, THIE_BACCRQ63GK3, THIE_BACCZ
Q5LCA7, THIE_BACFNQ64TA1, THIE_BACFRQ6HP17, THIE_BACHK
Q65DK0, THIE_BACLDA9VRN4, THIE_BACMKA8FIR6, THIE_BACP2
P39594, THIE_BACSUQ8AA13, THIE_BACTNA7ZA58, THIE_BACVZ
Q2KUS6, THIE_BORA1Q7WF72, THIE_BORBRQ7W3U2, THIE_BORPA
Q7W049, THIE_BORPEB9MN52, THIE_CALBDA8M9N4, THIE_CALMQ
Q8R806, THIE_CALS4A4XG66, THIE_CALS8A8FMD4, THIE_CAMJ8
Q9PNL3, THIE_CAMJEA1W068, THIE_CAMJJQ5HU23, THIE_CAMJR
B0SUK3, THIE_CAUSKA9WDL8, THIE_CHLAAQ5L6R5, THIE_CHLAB
Q824E9, THIE_CHLCVB3ED41, THIE_CHLL2Q3B4B1, THIE_CHLL3
B3QNM2, THIE_CHLP8A1BGM7, THIE_CHLPDA4SEP8, THIE_CHLPM
Q8KD79, THIE_CHLTEQ7P1R3, THIE_CHRVOA8AKT0, THIE_CITK8
Q97LQ9, THIE_CLOABA7FPT0, THIE_CLOB1C3L061, THIE_CLOB6
A6M1W6, THIE_CLOB8B2UY65, THIE_CLOBAB2TQ13, THIE_CLOBB
A5HYZ3, THIE_CLOBHC1FSC1, THIE_CLOBJB1IEG6, THIE_CLOBK
A7GAL0, THIE_CLOBLB1KV12, THIE_CLOBMQ186F8, THIE_CLOD6
A0Q2A0, THIE_CLONNQ0TQV4, THIE_CLOP1Q8XKQ8, THIE_CLOPE
Q0STA1, THIE_CLOPSQ893R0, THIE_CLOTEB5Y6I1, THIE_COPPD
Q8FP55, THIE_COREFQ4JVZ1, THIE_CORJKA7MJ80, THIE_CROS8
Q478V2, THIE_DECARQ1IX16, THIE_DEIGDQ9RYX9, THIE_DEIRA
B8FUD4, THIE_DESHDQ24XQ0, THIE_DESHYB5YA97, THIE_DICT6
B8E358, THIE_DICTDA7ZUK8, THIE_ECO24Q8X6Y0, THIE_ECO57
B5Z089, THIE_ECO5EA8A793, THIE_ECOHSA1AIG4, THIE_ECOK1
Q0TA72, THIE_ECOL5Q8FB78, THIE_ECOL6B1IUQ4, THIE_ECOLC
P30137, THIE_ECOLIB6I5K4, THIE_ECOSEQ1R5V9, THIE_ECOUT
A4W5B6, THIE_ENT38Q830K5, THIE_ENTFAQ2NB00, THIE_ERYLH
A5FJJ1, THIE_FLAJ1A6GWR9, THIE_FLAPJQ8RI59, THIE_FUSNN
Q5KZU0, THIE_GEOKAP61411, THIE_GEOSLA4IN28, THIE_GEOTN
Q7NNK8, THIE_GLOVIQ4QNC6, THIE_HAEI8A5UA71, THIE_HAEIE
A5UGT0, THIE_HAEIGP71350, THIE_HAEINQ9KCY8, THIE_HALH5
A1WYL4, THIE_HALHLQ5V0G6, THIE_HALMAQ18GX9, THIE_HALWD
Q1CT27, THIE_HELPHQ9ZL01, THIE_HELPJB2USY5, THIE_HELPS
O25514, THIE_HELPYA9AZD9, THIE_HERA2Q0I131, THIE_HISS1
B4U6B2, THIE_HYDS0Q0BXD3, THIE_HYPNAA6SUR1, THIE_JANMA
A6W6A2, THIE_KINRDA6TGQ0, THIE_KLEP7Q1ILG3, THIE_KORVE
B3W783, THIE_LACCBQ9CG48, THIE_LACLAA2RKJ7, THIE_LACLM
Q02YS6, THIE_LACLSQ03CB2, THIE_LACP3Q890C0, THIE_LACPL
C1DCM3, THIE_LARHHQ38ZM1, THIE_LATSSQ1MRJ6, THIE_LAWIP
B0SE83, THIE_LEPBAB0SMR9, THIE_LEPBPB1MX63, THIE_LEUCK
Q03NS1, THIE_LEVBAB2GBV5, THIE_LIMF3A5VKA1, THIE_LIMRD
B2G7Q4, THIE_LIMRJQ92EW5, THIE_LISINC1KZ34, THIE_LISMC
Q723Y9, THIE_LISMFB8DET0, THIE_LISMHQ8YA44, THIE_LISMO
A0AFC5, THIE_LISW6B1HX34, THIE_LYSSCQ65US7, THIE_MANSM
A1TYG6, THIE_MARN8Q8TMD6, THIE_METACQ0W1L8, THIE_METAR
A7IA09, THIE_METB6Q466J5, THIE_METBFQ602R3, THIE_METCA
Q1GXW1, THIE_METFKQ2FM63, THIE_METHJA4FX32, THIE_METM5
A9AAG9, THIE_METM6A6VG83, THIE_METM7Q8PS49, THIE_METMA
A3CS45, THIE_METMJP61413, THIE_METMPA5ULP4, THIE_METS3
A6UPE6, THIE_METVSQ2RGI8, THIE_MOOTAA0QLT6, THIE_MYCA1
P66917, THIE_MYCBOA1KFN6, THIE_MYCBPA4T2R5, THIE_MYCGI
B8ZU95, THIE_MYCLBQ9ZBL5, THIE_MYCLEB2HPZ9, THIE_MYCMM
P61412, THIE_MYCPAA0QQK7, THIE_MYCS2A3PTW9, THIE_MYCSJ
A1UAB4, THIE_MYCSKQ1BEL9, THIE_MYCSSA5TZE0, THIE_MYCTA
P9WG74, THIE_MYCTOP9WG75, THIE_MYCTUA0PRY2, THIE_MYCUA
A1T2Z5, THIE_MYCVPQ1D282, THIE_MYXXDQ3IP34, THIE_NATPD
Q5F5C2, THIE_NEIG1Q9JWI2, THIE_NEIMAQ9JXF7, THIE_NEIMB
Q0AFV0, THIE_NITECQ82UQ7, THIE_NITEUQ2Y5Q6, THIE_NITMU
Q3JDH3, THIE_NITOCQ5YNP9, THIE_NOCFAB2J6F7, THIE_NOSP7
Q8YX72, THIE_NOSS1Q8ESZ3, THIE_OCEIHQ7U5U1, THIE_PARMW
P57930, THIE_PASMUQ6DAM1, THIE_PECASQ03GM4, THIE_PEDPA
A5D4K4, THIE_PELTSQ4FN35, THIE_PELUBC0QR82, THIE_PERMH
Q7N964, THIE_PHOLLA6L645, THIE_PHOV8Q6KZH9, THIE_PICTO
A2CB21, THIE_PROM3Q7VAV5, THIE_PROMAB4EYU2, THIE_PROMH
Q7V8I3, THIE_PROMMQ7V0I3, THIE_PROMPA2BSJ5, THIE_PROMS
Q48DP2, THIE_PSE14A6V0D3, THIE_PSEA7B7V9E0, THIE_PSEA8
Q02SE4, THIE_PSEABQ9HX40, THIE_PSEAEQ1I4H6, THIE_PSEE4
Q4K5I7, THIE_PSEF5C3K2K2, THIE_PSEFSA4XYV5, THIE_PSEMY
A5W9G9, THIE_PSEP1Q3K6C1, THIE_PSEPFB0KJV8, THIE_PSEPG
Q88DP1, THIE_PSEPKB1J1Y7, THIE_PSEPWQ87VY6, THIE_PSESM
Q4ZNA1, THIE_PSEU2A5WDP0, THIE_PSYWFQ9UZQ5, THIE_PYRAB
Q8U192, THIE_PYRFUO58878, THIE_PYRHOO34294, THIE_RHIEC
Q7UQH1, THIE_RHOBAB6INN5, THIE_RHOCSA7NRF7, THIE_ROSCS
A5UUL3, THIE_ROSS1B8I3J4, THIE_RUMCHQ21MI9, THIE_SACD2
A4F727, THIE_SACENB5F1H6, THIE_SALA4A8M4E6, THIE_SALAI
A9MHD7, THIE_SALARQ57H62, THIE_SALCHB5FQK8, THIE_SALDC
B5QYE8, THIE_SALEPB5RFJ1, THIE_SALG2B4TCT2, THIE_SALHS
B4T0Z5, THIE_SALNSQ5PKA7, THIE_SALPAA9N0K5, THIE_SALPB
B5BJR2, THIE_SALPKQ2S2A8, THIE_SALRDB4TQK3, THIE_SALSV
Q8Z325, THIE_SALTIA4XBL2, THIE_SALTOQ9L9I8, THIE_SALTY
A8G8F3, THIE_SERP5B2TWI0, THIE_SHIB3Q31U04, THIE_SHIBS
Q32AG6, THIE_SHIDSQ0SY07, THIE_SHIF8Q83PB9, THIE_SHIFL
Q3YUZ1, THIE_SHISSQ5WH87, THIE_SHOC1C4XIJ2, THIE_SOLM1
A7X4S8, THIE_STAA1A6U3H7, THIE_STAA2Q2FF35, THIE_STAA3
Q2FWG3, THIE_STAA8A5IUN7, THIE_STAA9Q2YUL2, THIE_STAAB
Q5HEA8, THIE_STAACA6QIT5, THIE_STAAEP66918, THIE_STAAM
P66919, THIE_STAANQ6GEY4, THIE_STAARQ6G7L9, THIE_STAAS
Q8NVH5, THIE_STAAWQ9RGS5, THIE_STACTQ5HMD0, THIE_STAEQ
Q8CNK2, THIE_STAESQ4L7X3, THIE_STAHJQ49Z39, THIE_STAS1
Q3K1L6, THIE_STRA1Q8E5W9, THIE_STRA3Q8E092, THIE_STRA5
Q82AF9, THIE_STRAWQ9S2V2, THIE_STRCOA4W0K4, THIE_STRS2
A4VQX9, THIE_STUS1A5GMH7, THIE_SYNPWQ0IC17, THIE_SYNS3
Q3AL68, THIE_SYNSCQ0AZ86, THIE_SYNWWP72965, THIE_SYNY3
Q9HIQ4, THIE_THEACQ47R33, THIE_THEFYQ72KL8, THIE_THET2
Q5SKG9, THIE_THET8Q8DHK2, THIE_THEVBQ97BE8, THIE_THEVO
Q3SFU7, THIE_THIDAB8GLE3, THIE_THISHA7N7S3, THIE_VIBC1
Q87JW8, THIE_VIBPAQ7M9N9, THIE_WOLSUQ8PH45, THIE_XANAC
Q4UYA4, THIE_XANC8Q8P5R7, THIE_XANCPA7IGG9, THIE_XANP2
Q9PGC4, THIE_XYLFAQ87AX6, THIE_XYLFTA7FNH7, THIE_YERP3
Q1C1U8, THIE_YERPAQ8ZAQ1, THIE_YERPEQ1CN71, THIE_YERPN
A4TS25, THIE_YERPPQ66FP6, THIE_YERPSQ67T51, THIME_SYMTH
O26949, THIN_METTHQ5M731, TPS1L_ARATHO48881, TPS1_BRANA
Q2QWK9, TPS1_ORYSJ

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