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ENZYME entry: EC 2.5.1.87

Accepted Name
Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific).
Alternative Name(s)
Dehydrodolichyl diphosphate synthase 1.
Rer2p Z-prenyltransferase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55)
Comment(s)
  • The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation.
  • The yeast Saccharomyces cerevisiae has two different enzymes that catalyze this reaction.
  • Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits.
  • Largest Srt1p products reach C(290).
  • The enzyme from Arabidopsis thaliana catalyzes the formation of polyprenyl diphosphates with predominant carbon number C(120).
Cross-references
BRENDA2.5.1.87
EC2PDB2.5.1.87
ExplorEnz2.5.1.87
PRIAM enzyme-specific profiles2.5.1.87
KEGG Ligand Database for Enzyme Nomenclature2.5.1.87
IUBMB Enzyme Nomenclature2.5.1.87
IntEnz2.5.1.87
MEDLINEFind literature relating to 2.5.1.87
MetaCyc2.5.1.87
UniProtKB/Swiss-Prot
O80458, DDPS1_ARATH;  Q86SQ9, DHDDS_HUMAN;  Q99KU1, DHDDS_MOUSE;  
P9WFF6, DPDS_MYCTO;  P9WFF7, DPDS_MYCTU;  Q6DHR8, NGBR_DANRE;  
Q96E22, NGBR_HUMAN;  Q99LJ8, NGBR_MOUSE;  P35196, RER2_YEAST;  
Q03175, SRT1_YEAST;  A8B1Z2, UPPS_GIAIC;  Q9Y7K8, UPPS_SCHPO;  
Q12063, UPPS_YEAST;  O14171, YE54_SCHPO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
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