ENZYME

ENZYME entry: EC 2.5.1.87

Accepted Name

Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific).

Alternative Name(s)

Dehydrodolichyl diphosphate synthase 1.

Rer2p Z-prenyltransferase.

Reaction catalysed

(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate <=> n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55)

Comment(s)

The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation.
The yeast Saccharomyces cerevisiae has two different enzymes that catalyze this reaction.
Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits.
Largest Srt1p products reach C(290).
The enzyme from Arabidopsis thaliana catalyzes the formation of polyprenyl diphosphates with predominant carbon number C(120).

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature