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ENZYME entry: EC 2.7.1.163

Accepted Name
Hygromycin B 4-O-kinase.
Alternative Name(s)
Hygromycin-B kinase.
Reaction catalysed
ATP + hygromycin B <=> ADP + 4-O-phosphohygromycin B
Comment(s)
  • Phosphorylates the antibiotic hygromycin B.
  • Whereas the enzyme from Streptomyces hygroscopicus (EC 2.7.1.119) catalyzes the formation of 7''-O-phosphohygromycin B, this enzyme, found in Escherichia coli carrying a plasmid conferring resistance to hygromycin-B, forms 4-O-phosphohygromycin B.
  • Formerly EC 2.7.1.n6.
Cross-references
BRENDA2.7.1.163
EC2PDB2.7.1.163
ExplorEnz2.7.1.163
PRIAM enzyme-specific profiles2.7.1.163
KEGG Ligand Database for Enzyme Nomenclature2.7.1.163
IUBMB Enzyme Nomenclature2.7.1.163
IntEnz2.7.1.163
MEDLINEFind literature relating to 2.7.1.163
MetaCyc2.7.1.163
UniProtKB/Swiss-Prot
P00557, KHYB_ECOLX

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-