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ENZYME

ENZYME entry: EC 2.7.1.163

Accepted Name
hygromycin B 4-O-kinase
Alternative Name(s)
hygromycin-B kinase
Reaction catalysed
ATP + hygromycin B <=> 4-O-phosphohygromycin B + ADP + H(+)
Comment(s)
  • Phosphorylates the antibiotic hygromycin B.
  • Whereas the enzyme from Streptomyces hygroscopicus (EC 2.7.1.119) catalyzes the formation of 7''-O-phosphohygromycin B, this enzyme, found in Escherichia coli carrying a plasmid conferring resistance to hygromycin-B, forms 4-O-phosphohygromycin B.
  • Formerly EC 2.7.1.n6.
Cross-references
BRENDA2.7.1.163
EC2PDB2.7.1.163
ExplorEnz2.7.1.163
PRIAM enzyme-specific profiles2.7.1.163
KEGG Ligand Database for Enzyme Nomenclature2.7.1.163
IUBMB Enzyme Nomenclature2.7.1.163
IntEnz2.7.1.163
MEDLINEFind literature relating to 2.7.1.163
MetaCyc2.7.1.163
Rhea expert-curated reactions2.7.1.163
UniProtKB/Swiss-Prot
P00557, KHYB_ECOLX

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