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ENZYME

ENZYME entry: EC 2.7.1.68

Accepted Name
1-phosphatidylinositol-4-phosphate 5-kinase
Alternative Name(s)
diphosphoinositide kinase
phosphatidylinositol-4-phosphate 5-kinase
phosphatidylinositol 4-phosphate kinase
PIP kinase
PtdIns(4)P-5-kinase
type I PIP kinase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
Comment(s)
  • This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent.
  • The last of these reactions occurs in vivo and is physiologically relevant.
Cross-references
BRENDA2.7.1.68
EC2PDB2.7.1.68
ExplorEnz2.7.1.68
PRIAM enzyme-specific profiles2.7.1.68
KEGG Ligand Database for Enzyme Nomenclature2.7.1.68
IUBMB Enzyme Nomenclature2.7.1.68
IntEnz2.7.1.68
MEDLINEFind literature relating to 2.7.1.68
MetaCyc2.7.1.68
Rhea expert-curated reactions2.7.1.68
UniProtKB/Swiss-Prot
O13853, ITS3_SCHPOP38994, MSS4_YEASTQ99755, PI51A_HUMAN
P70182, PI51A_MOUSED3ZSI8, PI51A_RATQ5ZJ58, PI51B_CHICK
O14986, PI51B_HUMANP70181, PI51B_MOUSEQ5CZZ9, PI51B_RAT
O60331, PI51C_HUMANO70161, PI51C_MOUSEQ5I6B8, PI51C_RAT
Q8I239, PI51N_PLAF7Q56YP2, PI5K1_ARATHQ9W2R3, PI5K1_DROME
Q6EX42, PI5K1_ORYSJQ8L796, PI5K2_ARATHO48709, PI5K3_ARATH
Q9M1K2, PI5K4_ARATHQ9SLG9, PI5K5_ARATHQ9SFB8, PI5K6_ARATH
Q9SUI2, PI5K7_ARATHQ8RY89, PI5K8_ARATHQ8L850, PI5K9_ARATH
Q9LMN1, PI5KA_ARATHQ9M149, PI5KB_ARATHQ17QS4, PI5L1_BOVIN
Q5T9C9, PI5L1_HUMAN

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.1.-
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