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ENZYME entry: EC 2.7.10.2

Accepted Name
Non-specific protein-tyrosine kinase.
Alternative Name(s)
Cytoplasmic protein tyrosine kinase.
Reaction catalysed
ATP + a [protein]-L-tyrosine <=> ADP + a [protein]-L-tyrosine phosphate
Comment(s)
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
Cross-references
PROSITEPDOC00100
BRENDA2.7.10.2
EC2PDB2.7.10.2
ExplorEnz2.7.10.2
PRIAM enzyme-specific profiles2.7.10.2
KEGG Ligand Database for Enzyme Nomenclature2.7.10.2
IUBMB Enzyme Nomenclature2.7.10.2
IntEnz2.7.10.2
MEDLINEFind literature relating to 2.7.10.2
MetaCyc2.7.10.2
UniProtKB/Swiss-Prot
P03949, ABL1_CAEEL;  P00519, ABL1_HUMAN;  P00520, ABL1_MOUSE;  
P42684, ABL2_HUMAN;  Q4JIM5, ABL2_MOUSE;  P11681, ABL_CALVI;  
P00522, ABL_DROME;  P10447, ABL_FSVHY;  P00521, ABL_MLVAB;  
Q17R13, ACK1_BOVIN;  Q07912, ACK1_HUMAN;  O54967, ACK1_MOUSE;  
Q5U2X5, ACK1_RAT;  G5EBZ8, ARK1_CAEEL;  A2BIL7, BAZ1B_DANRE;  
Q9UIG0, BAZ1B_HUMAN;  Q9Z277, BAZ1B_MOUSE;  A8DZJ1, BAZ1B_XENLA;  
P51451, BLK_HUMAN;  P16277, BLK_MOUSE;  P51813, BMX_HUMAN;  
P97504, BMX_MOUSE;  P08630, BTKL_DROME;  Q8JH64, BTK_CHICK;  
Q06187, BTK_HUMAN;  P35991, BTK_MOUSE;  P39851, CAPB_STAAU;  
Q3K0T0, CPSD_STRA1;  Q04663, CPSD_STRA3;  Q9AFI1, CPSD_STRA5;  
P0C0T9, CPSD_STRAG;  Q54520, CPSD_STREE;  Q9AHD2, CPSD_STRPN;  
G5ECJ6, CSK1_CAEEL;  Q0VBZ0, CSK_BOVIN;  P41239, CSK_CHICK;  
P41240, CSK_HUMAN;  P41241, CSK_MOUSE;  P32577, CSK_RAT;  
P19525, E2AK2_HUMAN;  Q03963, E2AK2_MOUSE;  Q63184, E2AK2_RAT;  
Q00944, FAK1_CHICK;  Q05397, FAK1_HUMAN;  P34152, FAK1_MOUSE;  
O35346, FAK1_RAT;  Q91738, FAK1_XENLA;  Q14289, FAK2_HUMAN;  
Q9QVP9, FAK2_MOUSE;  P70600, FAK2_RAT;  Q9TTY2, FER_CANLF;  
P18106, FER_DROME;  P16591, FER_HUMAN;  P70451, FER_MOUSE;  
P09760, FER_RAT;  P14238, FES_FELCA;  P00542, FES_FSVGA;  
P00543, FES_FSVST;  P07332, FES_HUMAN;  P16879, FES_MOUSE;  
P00544, FGR_FSVGR;  P09769, FGR_HUMAN;  P14234, FGR_MOUSE;  
Q6P6U0, FGR_RAT;  P00541, FPS_AVISP;  P00530, FPS_FUJSV;  
Q22146, FRK1_CAEEL;  P42685, FRK_HUMAN;  Q922K9, FRK_MOUSE;  
Q62662, FRK_RAT;  Q6EWH2, FYNA_DANRE;  F1RDG9, FYNB_DANRE;  
A0JNB0, FYN_BOVIN;  Q05876, FYN_CHICK;  P06241, FYN_HUMAN;  
P39688, FYN_MOUSE;  A1Y2K1, FYN_PIG;  Q62844, FYN_RAT;  
P13406, FYN_XENLA;  P27446, FYN_XIPHE;  P08631, HCK_HUMAN;  
Q95M30, HCK_MACFA;  P08103, HCK_MOUSE;  P50545, HCK_RAT;  
P53356, HTK16_HYDVU;  Q08881, ITK_HUMAN;  Q03526, ITK_MOUSE;  
Q09178, JAK1_CYPCA;  O12990, JAK1_DANRE;  P23458, JAK1_HUMAN;  
P52332, JAK1_MOUSE;  Q75R65, JAK2_CHICK;  O60674, JAK2_HUMAN;  
Q62120, JAK2_MOUSE;  O19064, JAK2_PIG;  Q5RB23, JAK2_PONAB;  
Q62689, JAK2_RAT;  P52333, JAK3_HUMAN;  Q62137, JAK3_MOUSE;  
Q63272, JAK3_RAT;  Q24592, JAK_DROME;  Q5PU49, KPCD_CANLF;  
Q05655, KPCD_HUMAN;  P28867, KPCD_MOUSE;  F1N9Y5, KSYK_CHICK;  
P43405, KSYK_HUMAN;  P48025, KSYK_MOUSE;  Q00655, KSYK_PIG;  
Q64725, KSYK_RAT;  Q5PXS1, LCK_AOTNA;  P42683, LCK_CHICK;  
P06239, LCK_HUMAN;  P06240, LCK_MOUSE;  Q01621, LCK_RAT;  
Q95KR7, LCK_SAISC;  P07948, LYN_HUMAN;  P25911, LYN_MOUSE;  
Q07014, LYN_RAT;  Q1DB00, MASK_MYXXD;  P42679, MATK_HUMAN;  
P41242, MATK_MOUSE;  P41243, MATK_RAT;  Q14680, MELK_HUMAN;  
Q61846, MELK_MOUSE;  Q9H792, PEAK1_HUMAN;  Q69Z38, PEAK1_MOUSE;  
Q504Y2, PKDCC_HUMAN;  Q5RJI4, PKDCC_MOUSE;  Q9I7F7, PR2_DROME;  
Q86YV5, PRAG1_HUMAN;  Q571I4, PRAG1_MOUSE;  Q8H1G6, PTI11_ARATH;  
O49339, PTI12_ARATH;  B9DFG5, PTI13_ARATH;  Q13882, PTK6_HUMAN;  
Q64434, PTK6_MOUSE;  Q9HUF7, RFAP_PSEAE;  Q3SZJ2, RIPK2_BOVIN;  
O43353, RIPK2_HUMAN;  P58801, RIPK2_MOUSE;  P23049, SEA_AVIET;  
Q24145, SHARK_DROME;  Q10925, SID3_CAEEL;  A8WZ92, SPE8_CAEBR;  
O01798, SPE8_CAEEL;  P42687, SPK1_GIRTI;  P18160, SPLA_DICDI;  
P18161, SPLB_DICDI;  G5EE56, SRC1_CAEEL;  P13115, SRC1_XENLA;  
O45539, SRC2_CAEEL;  P13116, SRC2_XENLA;  Q9V9J3, SRC42_DROME;  
P00528, SRC64_DROME;  P15054, SRC_AVIS2;  P00525, SRC_AVISR;  
P14084, SRC_AVISS;  P14085, SRC_AVIST;  P00523, SRC_CHICK;  
Q1JPZ3, SRC_DANRE;  P12931, SRC_HUMAN;  P05480, SRC_MOUSE;  
Q9WUD9, SRC_RAT;  P25020, SRC_RSVH1;  P00526, SRC_RSVP;  
P31693, SRC_RSVPA;  P00524, SRC_RSVSA;  P63185, SRC_RSVSE;  
P42686, SRK1_SPOLA;  P42688, SRK2_SPOLA;  P42689, SRK3_SPOLA;  
P42690, SRK4_SPOLA;  Q9H3Y6, SRMS_HUMAN;  Q62270, SRMS_MOUSE;  
O75716, STK16_HUMAN;  O88697, STK16_MOUSE;  P57760, STK16_RAT;  
P17713, STK_HYDVU;  Q6J9G0, STYK1_HUMAN;  Q6J9G1, STYK1_MOUSE;  
P42680, TEC_HUMAN;  P24604, TEC_MOUSE;  Q13470, TNK1_HUMAN;  
Q99ML2, TNK1_MOUSE;  P42681, TXK_HUMAN;  P42682, TXK_MOUSE;  
P29597, TYK2_HUMAN;  Q9R117, TYK2_MOUSE;  O36385, VG36_ALHV1;  
Q8AYK6, WEE1A_XENLA;  Q8QGV2, WEE1B_XENLA;  Q8L4H0, WEE1_ARATH;  
P54350, WEE1_DROME;  P30291, WEE1_HUMAN;  P47810, WEE1_MOUSE;  
Q6Z829, WEE1_ORYSJ;  Q63802, WEE1_RAT;  P07527, WEE1_SCHPO;  
P47817, WEE2A_XENLA;  O57473, WEE2B_XENLA;  Q6DFE0, WEE2C_XENLA;  
D2HHP1, WEE2_AILME;  E2RSS3, WEE2_CANLF;  E1BTE1, WEE2_CHICK;  
Q1LX51, WEE2_DANRE;  P0C1S8, WEE2_HUMAN;  Q66JT0, WEE2_MOUSE;  
A4PES0, WEE2_PIG;  A4QNA8, WEE2_XENTR;  Q9LSC2, Y3589_ARATH;  
P00527, YES_AVISY;  Q28923, YES_CANLF;  P09324, YES_CHICK;  
A1A5H8, YES_DANRE;  P07947, YES_HUMAN;  Q04736, YES_MOUSE;  
F1LM93, YES_RAT;  P10936, YES_XENLA;  P27447, YES_XIPHE;  
Q02977, YRK_CHICK;  Q54G28, YTYK1_DICDI;  Q54R58, YTYK2_DICDI;  
P71051, YVEL_BACSU;  P96716, YWQD_BACSU;  Q11112, YX05_CAEEL;  
P43403, ZAP70_HUMAN;  P43404, ZAP70_MOUSE;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.10.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-