ENZYME entry: EC 2.7.11.11

Accepted Name
cAMP-dependent protein kinase.
Alternative Name(s)
PKA.
PKA C.
Protein kinase A.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • cAMP is required to activate this enzyme.
  • The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits.
  • cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C).
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.11
EC2PDB2.7.11.11
ExplorEnz2.7.11.11
PRIAM enzyme-specific profiles2.7.11.11
KEGG Ligand Database for Enzyme Nomenclature2.7.11.11
IUBMB Enzyme Nomenclature2.7.11.11
IntEnz2.7.11.11
MEDLINEFind literature relating to 2.7.11.11
MetaCyc2.7.11.11
UniProtKB/Swiss-Prot
P06244, KAPA_YEAST;  P40376, KAPB_SCHPO;  P06245, KAPB_YEAST;  
A8XW88, KAPC1_CAEBR;  P21137, KAPC1_CAEEL;  A8XJQ6, KAPC2_CAEBR;  
Q7JP68, KAPC2_CAEEL;  P00517, KAPCA_BOVIN;  Q8MJ44, KAPCA_CANLF;  
P25321, KAPCA_CRIGR;  P17612, KAPCA_HUMAN;  P05132, KAPCA_MOUSE;  
P36887, KAPCA_PIG;  P27791, KAPCA_RAT;  Q9MZD9, KAPCA_SHEEP;  
P05131, KAPCB_BOVIN;  P68180, KAPCB_CRIGR;  P22694, KAPCB_HUMAN;  
P68181, KAPCB_MOUSE;  P05383, KAPCB_PIG;  P68182, KAPCB_RAT;  
P22612, KAPCG_HUMAN;  O62846, KAPCG_MACMU;  P49673, KAPC_ASCSU;  
P34099, KAPC_DICDI;  P12370, KAPC_DROME;  Q8SRK8, KAPC_ENCCU;  
P05986, KAPC_YEAST;  

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