ENZYME entry: EC 2.7.11.21

Accepted Name
Polo kinase.
Alternative Name(s)
PLK.
Polo serine-threonine kinase.
Polo-like kinase.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation.
  • The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein.
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.21
EC2PDB2.7.11.21
ExplorEnz2.7.11.21
PRIAM enzyme-specific profiles2.7.11.21
KEGG Ligand Database for Enzyme Nomenclature2.7.11.21
IUBMB Enzyme Nomenclature2.7.11.21
IntEnz2.7.11.21
MEDLINEFind literature relating to 2.7.11.21
MetaCyc2.7.11.21
UniProtKB/Swiss-Prot
P0C8M8, CCR1_MAIZE;  Q8SWM6, CDC5_ENCCU;  P32562, CDC5_YEAST;  
Q2TA25, PLK1_BOVIN;  P34331, PLK1_CAEEL;  P53350, PLK1_HUMAN;  
Q07832, PLK1_MOUSE;  Q62673, PLK1_RAT;  P70032, PLK1_XENLA;  
P62205, PLK1_XENTR;  Q9N2L7, PLK2_CAEEL;  Q9NYY3, PLK2_HUMAN;  
P53351, PLK2_MOUSE;  Q5R4L1, PLK2_PONAB;  Q9R012, PLK2_RAT;  
Q20845, PLK3_CAEEL;  Q9H4B4, PLK3_HUMAN;  Q60806, PLK3_MOUSE;  
Q9R011, PLK3_RAT;  Q16W24, PLK4_AEDAE;  A2VDZ4, PLK4_BOVIN;  
B0WAU8, PLK4_CULQU;  Q7ZVS3, PLK4_DANRE;  B3M6I4, PLK4_DROAN;  
B3NE99, PLK4_DROER;  B4J3F1, PLK4_DROGR;  O97143, PLK4_DROME;  
B4KYX8, PLK4_DROMO;  B4HBU3, PLK4_DROPE;  Q2LYK3, PLK4_DROPS;  
B4IAQ8, PLK4_DROSE;  B4QK53, PLK4_DROSI;  B4LDJ6, PLK4_DROVI;  
B4MXR8, PLK4_DROWI;  B4PDM5, PLK4_DROYA;  O00444, PLK4_HUMAN;  
Q64702, PLK4_MOUSE;  A7SNN5, PLK4_NEMVE;  Q5R9Z7, PLK4_PONAB;  
B2GUY1, PLK4_RAT;  Q6PAD2, PLK4_XENLA;  B3DL84, PLK4_XENTR;  
P50528, PLO1_SCHPO;  P52304, POLO_DROME;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-