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ENZYME entry: EC 2.7.12.2

Accepted Name
Mitogen-activated protein kinase kinase.
Alternative Name(s)
MAP kinase kinase.
MAP2K.
MAPKK.
MEK.
MKK.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation.
  • It is required for activation of EC 2.7.11.24.
  • Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
Cross-references
PROSITEPDOC00100
BRENDA2.7.12.2
EC2PDB2.7.12.2
ExplorEnz2.7.12.2
PRIAM enzyme-specific profiles2.7.12.2
KEGG Ligand Database for Enzyme Nomenclature2.7.12.2
IUBMB Enzyme Nomenclature2.7.12.2
IntEnz2.7.12.2
MEDLINEFind literature relating to 2.7.12.2
MetaCyc2.7.12.2
UniProtKB/Swiss-Prot
P10506, BYR1_SCHPO;  Q24324, DSOR1_DROME;  P85051, DYR1A_RABIT;  
Q63470, DYR1A_RAT;  Q99078, FUZ7_USTMA;  Q23977, HEP_DROME;  
G5EDT6, JKK1_CAEEL;  Q9LQM8, M2K10_ARATH;  Q94A06, M2K1_ARATH;  
Q5QN75, M2K1_ORYSJ;  Q9S7U9, M2K2_ARATH;  O80396, M2K3_ARATH;  
O80397, M2K4_ARATH;  Q8RXG3, M2K5_ARATH;  Q9FJV0, M2K6_ARATH;  
Q9LPQ3, M2K7_ARATH;  Q9M8J5, M2K8_ARATH;  Q9FX43, M2K9_ARATH;  
Q21307, MEK1_CAEEL;  Q10664, MEK2_CAEEL;  P32490, MKK1_YEAST;  
P32491, MKK2_YEAST;  Q20347, MKK4_CAEEL;  Q63980, MP2K1_CRIGR;  
Q55CL6, MP2K1_DICDI;  Q02750, MP2K1_HUMAN;  P31938, MP2K1_MOUSE;  
Q9XT09, MP2K1_PANTR;  P29678, MP2K1_RABIT;  Q01986, MP2K1_RAT;  
Q91447, MP2K1_SERCA;  Q05116, MP2K1_XENLA;  Q1HG70, MP2K2_CANLF;  
Q90891, MP2K2_CHICK;  Q90321, MP2K2_CYPCA;  P36507, MP2K2_HUMAN;  
Q63932, MP2K2_MOUSE;  P36506, MP2K2_RAT;  Q07192, MP2K2_XENLA;  
P46734, MP2K3_HUMAN;  O09110, MP2K3_MOUSE;  P39746, MP2K3_XENLA;  
P45985, MP2K4_HUMAN;  P47809, MP2K4_MOUSE;  Q13163, MP2K5_HUMAN;  
Q9WVS7, MP2K5_MOUSE;  Q62862, MP2K5_RAT;  Q5E9X2, MP2K6_BOVIN;  
Q9DGE0, MP2K6_DANRE;  P52564, MP2K6_HUMAN;  P70236, MP2K6_MOUSE;  
O14733, MP2K7_HUMAN;  Q8CE90, MP2K7_MOUSE;  Q4KSH7, MP2K7_RAT;  
O94235, MPH1L_SCHPO;  Q8SSH4, MPS1_ENCCU;  P54199, MPS1_YEAST;  
P08018, PBS2_YEAST;  G5EDF7, SEK1_CAEEL;  Q9Y884, SKH1_SCHPO;  
Q5A6T5, STE7_CANAL;  C4YLK8, STE7_CANAW;  P0CY25, STE7_CANAX;  
P06784, STE7_YEAST;  Q6DHU8, TOPK_DANRE;  Q96KB5, TOPK_HUMAN;  
Q9JJ78, TOPK_MOUSE;  P33886, WIS1_SCHPO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.12.-
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