To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.7.11.24

Accepted Name
Mitogen-activated protein kinase.
Alternative Name(s)
C-Jun N-terminal kinase.
ERK.
Extracellular signal-regulated kinase.
JNK.
MAP kinase.
MAPK.
MBP kinase I.
MBP kinase II.
Microtubule-associated protein 2 kinase.
Microtubule-associated protein kinase.
Myelin basic protein kinase.
SAPK.
Stress-activated protein kinase.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation.
  • Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline.
  • A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY).
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100 ; PDOC01049
BRENDA2.7.11.24
EC2PDB2.7.11.24
ExplorEnz2.7.11.24
PRIAM enzyme-specific profiles2.7.11.24
KEGG Ligand Database for Enzyme Nomenclature2.7.11.24
IUBMB Enzyme Nomenclature2.7.11.24
IntEnz2.7.11.24
MEDLINEFind literature relating to 2.7.11.24
MetaCyc2.7.11.24
UniProtKB/Swiss-Prot
P0CP67, CPK1_CRYNB;  P0CP66, CPK1_CRYNJ;  Q5A1D3, ERK1_CANAL;  
C4YGK0, ERK1_CANAW;  P42525, ERK1_DICDI;  Q54QB1, ERK2_DICDI;  
P40417, ERKA_DROME;  P16892, FUS3_YEAST;  A3EZ55, HOG1A_WALI9;  
M1T7M3, HOG1B_WALI9;  Q52PH6, HOG1_ALTBR;  Q750A9, HOG1_ASHGO;  
A1CPG7, HOG1_ASPCL;  Q4WSF6, HOG1_ASPFU;  Q38HL5, HOG1_ASPGL;  
A2QRF6, HOG1_ASPNC;  Q0D0P5, HOG1_ASPTN;  Q6PWX2, HOG1_BEABA;  
Q702W0, HOG1_BLAAD;  Q8TGA9, HOG1_BLUGR;  A1IVT7, HOG1_BOTFB;  
Q92207, HOG1_CANAL;  Q6FIU2, HOG1_CANGA;  Q2H332, HOG1_CHAGB;  
Q4W6D3, HOG1_COCHE;  Q1DUU8, HOG1_COCIM;  Q2WFL5, HOG1_COCMI;  
Q75Q66, HOG1_COLOR;  P0CP69, HOG1_CRYNB;  Q56R42, HOG1_CRYNH;  
P0CP68, HOG1_CRYNJ;  Q875L0, HOG1_CRYPA;  Q9UV50, HOG1_DEBHA;  
Q9P419, HOG1_EMENI;  Q4PNJ1, HOG1_FUSCU;  Q4PKS0, HOG1_GIBIN;  
P0C431, HOG1_GIBZE;  Q8NJT7, HOG1_HORWE;  Q6XKY3, HOG1_HYPAT;  
Q6CJA8, HOG1_KLULA;  Q9UV51, HOG1_MAGO7;  A1D2C9, HOG1_NEOFI;  
Q96TL5, HOG1_NEUCR;  Q0U4L8, HOG1_PHANO;  A3LN91, HOG1_PICST;  
Q09892, HOG1_SCHPO;  Q5I6M2, HOG1_SETTU;  Q1L5Z8, HOG1_TORDE;  
Q2WGK3, HOG1_TRIHA;  Q4PC06, HOG1_USTMA;  A3EZ53, HOG1_WALMU;  
A3EZ54, HOG1_WALSE;  Q6C4M9, HOG1_YARLI;  P32485, HOG1_YEAST;  
O93982, HOG1_ZYGRC;  O59854, HOG1_ZYGRO;  Q1KTF2, HOG1_ZYMTI;  
O59853, HOG2_ZYGRO;  Q9U6D2, JNK1_ANCCA;  Q8WQG9, JNK1_CAEEL;  
P92208, JNK_DROME;  Q966Y3, JNK_SUBDO;  O44408, KGB1_CAEEL;  
P14681, KSS1_YEAST;  O94737, MAPK1_PNECA;  O42781, MAPK2_PNECA;  
Q00859, MAPK_FUSSO;  P46196, MK01_BOVIN;  P28482, MK01_HUMAN;  
P63085, MK01_MOUSE;  P63086, MK01_RAT;  P26696, MK01_XENLA;  
P27361, MK03_HUMAN;  Q63844, MK03_MOUSE;  P21708, MK03_RAT;  
P31152, MK04_HUMAN;  Q6P5G0, MK04_MOUSE;  Q63454, MK04_RAT;  
Q5F3W3, MK06_CHICK;  Q16659, MK06_HUMAN;  Q61532, MK06_MOUSE;  
Q5R7U1, MK06_PONAB;  P27704, MK06_RAT;  A5PKJ4, MK07_BOVIN;  
Q13164, MK07_HUMAN;  Q9WVS8, MK07_MOUSE;  P0C865, MK07_RAT;  
Q90327, MK08A_CYPCA;  O42099, MK08B_CYPCA;  Q9DGD9, MK08_DANRE;  
P45983, MK08_HUMAN;  Q91Y86, MK08_MOUSE;  P49185, MK08_RAT;  
Q8QHK8, MK08_XENLA;  P79996, MK09_CHICK;  P45984, MK09_HUMAN;  
Q9WTU6, MK09_MOUSE;  P49186, MK09_RAT;  P53779, MK10_HUMAN;  
Q61831, MK10_MOUSE;  P49187, MK10_RAT;  Q15759, MK11_HUMAN;  
Q9WUI1, MK11_MOUSE;  O42376, MK12_DANRE;  P53778, MK12_HUMAN;  
O08911, MK12_MOUSE;  Q63538, MK12_RAT;  Q3T0N5, MK13_BOVIN;  
O15264, MK13_HUMAN;  Q9Z1B7, MK13_MOUSE;  Q9N272, MK13_PANTR;  
Q9WTY9, MK13_RAT;  Q90336, MK14A_CYPCA;  Q9DGE2, MK14A_DANRE;  
O62618, MK14A_DROME;  Q9I958, MK14B_CYPCA;  Q9DGE1, MK14B_DANRE;  
O61443, MK14B_DROME;  P83100, MK14C_DROME;  O02812, MK14_CANLF;  
Q16539, MK14_HUMAN;  P47811, MK14_MOUSE;  Q95NE7, MK14_PANTR;  
P70618, MK14_RAT;  P47812, MK14_XENLA;  Q8TD08, MK15_HUMAN;  
Q80Y86, MK15_MOUSE;  Q9Z2A6, MK15_RAT;  Q5AAG6, MKC1_CANAL;  
P43068, MKC1_CANAX;  Q07176, MMK1_MEDSA;  Q40353, MMK2_MEDSA;  
O81472, MP3K2_ARATH;  Q9M1Z5, MPK10_ARATH;  Q5ZCI1, MPK10_ORYSJ;  
Q9LMM5, MPK11_ARATH;  Q5VN19, MPK11_ORYSJ;  Q8GYQ5, MPK12_ARATH;  
Q5Z9J0, MPK12_ORYSJ;  Q9LQQ9, MPK13_ARATH;  A2X0M1, MPK13_ORYSI;  
Q0E459, MPK13_ORYSJ;  O23236, MPK14_ARATH;  Q75KK8, MPK14_ORYSJ;  
Q9C9U4, MPK15_ARATH;  Q53N72, MPK15_ORYSJ;  Q8W4J2, MPK16_ARATH;  
Q5VP69, MPK16_ORYSJ;  Q84M93, MPK17_ARATH;  Q6L5F7, MPK17_ORYSJ;  
Q9C5C0, MPK18_ARATH;  Q9LUC3, MPK19_ARATH;  Q39021, MPK1_ARATH;  
P39745, MPK1_CAEEL;  Q84UI5, MPK1_ORYSJ;  Q9SJG9, MPK20_ARATH;  
Q39022, MPK2_ARATH;  Q5J4W4, MPK2_ORYSJ;  Q39023, MPK3_ARATH;  
Q6Z437, MPK3_ORYSJ;  Q39024, MPK4_ARATH;  Q5Z859, MPK4_ORYSJ;  
Q39025, MPK5_ARATH;  A2XFC8, MPK5_ORYSI;  Q10N20, MPK5_ORYSJ;  
Q39026, MPK6_ARATH;  Q336X9, MPK6_ORYSJ;  Q39027, MPK7_ARATH;  
Q67C40, MPK7_ORYSJ;  Q9LM33, MPK8_ARATH;  Q5SN53, MPK8_ORYSJ;  
Q9LV37, MPK9_ARATH;  Q6L5D4, MPK9_ORYSJ;  A1CAF0, MPKC_ASPCL;  
Q4WUN7, MPKC_ASPFU;  A2QN07, MPKC_ASPNC;  Q2U469, MPKC_ASPOR;  
Q0CIC7, MPKC_ASPTN;  Q9HG11, MPKC_EMENI;  A1DES4, MPKC_NEOFI;  
Q06060, MPK_PEA;  Q40884, MPK_PETHY;  Q8QGV6, NLK2_XENLA;  
B1H3E1, NLK2_XENTR;  E1BMN8, NLK_BOVIN;  A8XSC1, NLK_CAEBR;  
Q9U9Y8, NLK_CAEEL;  E2QWQ2, NLK_CANLF;  Q9UBE8, NLK_HUMAN;  
O54949, NLK_MOUSE;  D3ZSZ3, NLK_RAT;  Q40517, NTF3_TOBAC;  
Q40532, NTF4_TOBAC;  Q40531, NTF6_TOBAC;  Q17446, PMK1_CAEEL;  
Q8MXI4, PMK2_CAEEL;  O44514, PMK3_CAEEL;  Q00772, SLT2_YEAST;  
G5EBT1, SMA5_CAEEL;  P41808, SMK1_YEAST;  P27638, SPK1_SCHPO;  
Q92398, SPM1_SCHPO;  Q11179, YPC2_CAEEL;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.11.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-