ENZYME entry: EC 2.7.11.24

Accepted Name
Mitogen-activated protein kinase.
Alternative Name(s)
C-Jun N-terminal kinase.
ERK.
Extracellular signal-regulated kinase.
JNK.
MAP kinase.
MAPK.
MBP kinase I.
MBP kinase II.
Microtubule-associated protein 2 kinase.
Microtubule-associated protein kinase.
Myelin basic protein kinase.
SAPK.
Stress-activated protein kinase.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation.
  • Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline.
  • A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY).
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
Cross-references
PROSITEPDOC00100 ; PDOC01049
BRENDA2.7.11.24
EC2PDB2.7.11.24
ExplorEnz2.7.11.24
PRIAM enzyme-specific profiles2.7.11.24
KEGG Ligand Database for Enzyme Nomenclature2.7.11.24
IUBMB Enzyme Nomenclature2.7.11.24
IntEnz2.7.11.24
MEDLINEFind literature relating to 2.7.11.24
MetaCyc2.7.11.24
UniProtKB/Swiss-Prot
P0CP67, CPK1_CRYNB;  P0CP66, CPK1_CRYNJ;  Q5A1D3, ERK1_CANAL;  
C4YGK0, ERK1_CANAW;  P42525, ERK1_DICDI;  Q54QB1, ERK2_DICDI;  
P40417, ERKA_DROME;  P16892, FUS3_YEAST;  A3EZ55, HOG1A_WALI9;  
M1T7M3, HOG1B_WALI9;  Q52PH6, HOG1_ALTBR;  Q750A9, HOG1_ASHGO;  
A1CPG7, HOG1_ASPCL;  Q4WSF6, HOG1_ASPFU;  A2QRF6, HOG1_ASPNC;  
Q0D0P5, HOG1_ASPTN;  Q6PWX2, HOG1_BEABA;  Q702W0, HOG1_BLAAD;  
Q8TGA9, HOG1_BLUGR;  A1IVT7, HOG1_BOTFB;  Q92207, HOG1_CANAL;  
Q6FIU2, HOG1_CANGA;  Q2H332, HOG1_CHAGB;  Q4W6D3, HOG1_COCHE;  
Q1DUU8, HOG1_COCIM;  Q2WFL5, HOG1_COCMI;  Q75Q66, HOG1_COLOR;  
P0CP69, HOG1_CRYNB;  Q56R42, HOG1_CRYNH;  P0CP68, HOG1_CRYNJ;  
Q875L0, HOG1_CRYPA;  Q9UV50, HOG1_DEBHA;  Q9P419, HOG1_EMENI;  
Q38HL5, HOG1_EURHE;  Q4PNJ1, HOG1_FUSCU;  Q4PKS0, HOG1_GIBIN;  
P0C431, HOG1_GIBZE;  Q8NJT7, HOG1_HORWE;  Q6XKY3, HOG1_HYPAT;  
Q6CJA8, HOG1_KLULA;  Q9UV51, HOG1_MAGO7;  Q1KTF2, HOG1_MYCGM;  
A1D2C9, HOG1_NEOFI;  Q96TL5, HOG1_NEUCR;  Q0U4L8, HOG1_PHANO;  
A3LN91, HOG1_PICST;  Q09892, HOG1_SCHPO;  Q5I6M2, HOG1_SETTU;  
Q1L5Z8, HOG1_TORDE;  Q2WGK3, HOG1_TRIHA;  Q4PC06, HOG1_USTMA;  
A3EZ53, HOG1_WALMU;  A3EZ54, HOG1_WALSE;  Q6C4M9, HOG1_YARLI;  
P32485, HOG1_YEAST;  O93982, HOG1_ZYGRC;  O59854, HOG1_ZYGRO;  
O59853, HOG2_ZYGRO;  Q9U6D2, JNK1_ANCCA;  Q8WQG9, JNK1_CAEEL;  
P92208, JNK_DROME;  Q966Y3, JNK_SUBDO;  P14681, KSS1_YEAST;  
O94737, MAPK1_PNECA;  O42781, MAPK2_PNECA;  Q00859, MAPK_FUSSO;  
P46196, MK01_BOVIN;  P28482, MK01_HUMAN;  P63085, MK01_MOUSE;  
P63086, MK01_RAT;  P26696, MK01_XENLA;  P27361, MK03_HUMAN;  
Q63844, MK03_MOUSE;  P21708, MK03_RAT;  P31152, MK04_HUMAN;  
Q6P5G0, MK04_MOUSE;  Q63454, MK04_RAT;  Q5F3W3, MK06_CHICK;  
Q16659, MK06_HUMAN;  Q61532, MK06_MOUSE;  Q5R7U1, MK06_PONAB;  
P27704, MK06_RAT;  A5PKJ4, MK07_BOVIN;  Q13164, MK07_HUMAN;  
Q9WVS8, MK07_MOUSE;  P0C865, MK07_RAT;  Q90327, MK08A_CYPCA;  
O42099, MK08B_CYPCA;  Q9DGD9, MK08_DANRE;  P45983, MK08_HUMAN;  
Q91Y86, MK08_MOUSE;  P49185, MK08_RAT;  Q8QHK8, MK08_XENLA;  
P79996, MK09_CHICK;  P45984, MK09_HUMAN;  Q9WTU6, MK09_MOUSE;  
P49186, MK09_RAT;  P53779, MK10_HUMAN;  Q61831, MK10_MOUSE;  
P49187, MK10_RAT;  Q15759, MK11_HUMAN;  Q9WUI1, MK11_MOUSE;  
O42376, MK12_DANRE;  P53778, MK12_HUMAN;  O08911, MK12_MOUSE;  
Q63538, MK12_RAT;  Q3T0N5, MK13_BOVIN;  O15264, MK13_HUMAN;  
Q9Z1B7, MK13_MOUSE;  Q9N272, MK13_PANTR;  Q9WTY9, MK13_RAT;  
Q90336, MK14A_CYPCA;  Q9DGE2, MK14A_DANRE;  O62618, MK14A_DROME;  
Q9I958, MK14B_CYPCA;  Q9DGE1, MK14B_DANRE;  O61443, MK14B_DROME;  
P83100, MK14C_DROME;  O02812, MK14_CANFA;  Q16539, MK14_HUMAN;  
P47811, MK14_MOUSE;  Q95NE7, MK14_PANTR;  P70618, MK14_RAT;  
P47812, MK14_XENLA;  Q8TD08, MK15_HUMAN;  Q80Y86, MK15_MOUSE;  
Q9Z2A6, MK15_RAT;  P43068, MKC1_CANAX;  Q07176, MMK1_MEDSA;  
Q40353, MMK2_MEDSA;  Q9M1Z5, MPK10_ARATH;  Q5ZCI1, MPK10_ORYSJ;  
Q9LMM5, MPK11_ARATH;  Q5VN19, MPK11_ORYSJ;  Q8GYQ5, MPK12_ARATH;  
Q5Z9J0, MPK12_ORYSJ;  Q9LQQ9, MPK13_ARATH;  A2X0M1, MPK13_ORYSI;  
Q0E459, MPK13_ORYSJ;  O23236, MPK14_ARATH;  Q75KK8, MPK14_ORYSJ;  
Q9C9U4, MPK15_ARATH;  Q53N72, MPK15_ORYSJ;  Q8W4J2, MPK16_ARATH;  
Q5VP69, MPK16_ORYSJ;  Q84M93, MPK17_ARATH;  Q6L5F7, MPK17_ORYSJ;  
Q9C5C0, MPK18_ARATH;  Q9LUC3, MPK19_ARATH;  Q39021, MPK1_ARATH;  
Q84UI5, MPK1_ORYSJ;  Q9SJG9, MPK20_ARATH;  Q39022, MPK2_ARATH;  
Q5J4W4, MPK2_ORYSJ;  Q39023, MPK3_ARATH;  Q6Z437, MPK3_ORYSJ;  
Q39024, MPK4_ARATH;  Q5Z859, MPK4_ORYSJ;  Q39025, MPK5_ARATH;  
A2XFC8, MPK5_ORYSI;  Q10N20, MPK5_ORYSJ;  Q39026, MPK6_ARATH;  
Q336X9, MPK6_ORYSJ;  Q39027, MPK7_ARATH;  Q67C40, MPK7_ORYSJ;  
Q9LM33, MPK8_ARATH;  Q5SN53, MPK8_ORYSJ;  Q9LV37, MPK9_ARATH;  
Q6L5D4, MPK9_ORYSJ;  A1CAF0, MPKC_ASPCL;  Q4WUN7, MPKC_ASPFU;  
A2QN07, MPKC_ASPNC;  Q2U469, MPKC_ASPOR;  Q0CIC7, MPKC_ASPTN;  
Q9HG11, MPKC_EMENI;  A1DES4, MPKC_NEOFI;  Q06060, MPK_PEA;  
Q40884, MPK_PETHY;  Q8QGV6, NLK2_XENLA;  B1H3E1, NLK2_XENTR;  
E1BMN8, NLK_BOVIN;  A8XSC1, NLK_CAEBR;  Q9U9Y8, NLK_CAEEL;  
E2QWQ2, NLK_CANFA;  Q9UBE8, NLK_HUMAN;  O54949, NLK_MOUSE;  
D3ZSZ3, NLK_RAT;  Q40517, NTF3_TOBAC;  Q40532, NTF4_TOBAC;  
Q40531, NTF6_TOBAC;  Q17446, PMK1_CAEEL;  Q8MXI4, PMK2_CAEEL;  
O44514, PMK3_CAEEL;  Q00772, SLT2_YEAST;  P41808, SMK1_YEAST;  
P27638, SPK1_SCHPO;  Q92398, SPM1_SCHPO;  P39745, SUR1_CAEEL;  
Q11179, YPC2_CAEEL;  

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