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ENZYME

ENZYME entry: EC 2.7.7.2

Accepted Name
FAD synthase
Alternative Name(s)
FAD diphosphorylase
FAD pyrophosphorylase
FADS
flavin adenine dinucleotide synthetase
FMN adenylyltransferase
Reaction catalysed
ATP + FMN + H(+) <=> diphosphate + FAD
Comment(s)
  • Highly specific for ATP as phosphate donor.
  • The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates.
  • While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26.
Cross-references
BRENDA2.7.7.2
EC2PDB2.7.7.2
ExplorEnz2.7.7.2
PRIAM enzyme-specific profiles2.7.7.2
KEGG Ligand Database for Enzyme Nomenclature2.7.7.2
IUBMB Enzyme Nomenclature2.7.7.2
IntEnz2.7.7.2
MEDLINEFind literature relating to 2.7.7.2
MetaCyc2.7.7.2
Rhea expert-curated reactions2.7.7.2
UniProtKB/Swiss-Prot
Q626I0, FAD1_CAEBRQ22017, FAD1_CAEELQ68EH8, FAD1_DANRE
Q8NFF5, FAD1_HUMANQ8R123, FAD1_MOUSEQ5RCH4, FAD1_PONAB
O74841, FAD1_SCHPOP38913, FAD1_YEASTQ6ING7, FLAD1_XENLA
Q7NBZ0, MNMA_MYCGAQ8Y7F2, RIBCF_LISMOP54575, RIBC_BACSU
Q8Y914, RIBC_LISMOQ9FMW8, RIBF1_ARATHQ8VZR0, RIBF2_ARATH
P57250, RIBF_BUCAIQ8K9Z1, RIBF_BUCAPQ59263, RIBF_CORAM
P0AG42, RIBF_ECO57P0AG41, RIBF_ECOL6P0AG40, RIBF_ECOLI
A4IT50, RIBF_GEOTNP44957, RIBF_HAEINP47391, RIBF_MYCGE
P75587, RIBF_MYCPNQ10BX9, RIBF_ORYSJP22990, RIBF_PSEFL
O84990, RIBF_RHOOPP0AG43, RIBF_SHIFLP73651, RIBF_SYNY3
B5I9H4, RIBL_ACIB4O28854, RIBL_ARCFUD2RES5, RIBL_ARCPA
D3RZA9, RIBL_FERPAD8J4S4, RIBL_HALJBB9LSN4, RIBL_HALLT
C7P4K0, RIBL_HALMDB0R450, RIBL_HALS3Q9HRB2, RIBL_HALSA
D2RTP8, RIBL_HALTVC7NTR1, RIBL_HALUDD4GVJ2, RIBL_HALVD
B1L7J8, RIBL_KORCOA6UWK8, RIBL_META3Q8TPT5, RIBL_METAC
Q0W933, RIBL_METARA7I4S0, RIBL_METB6Q46AS7, RIBL_METBF
Q12YR1, RIBL_METBUD7E8Z9, RIBL_METEZC7P607, RIBL_METFA
E3GWN9, RIBL_METFVQ2FT79, RIBL_METHJD5VUB0, RIBL_METIM
Q58579, RIBL_METJAQ8TXT2, RIBL_METKAA2SQH8, RIBL_METLZ
A4FXX6, RIBL_METM5A9AB01, RIBL_METM6A6VFN4, RIBL_METM7
Q8Q095, RIBL_METMAA3CXW9, RIBL_METMJQ6LYP5, RIBL_METMP
D5EBS7, RIBL_METMSE1RHM5, RIBL_METP4B8GJN8, RIBL_METPE
D1YZF2, RIBL_METPSD3DZ18, RIBL_METRMA5ULI6, RIBL_METS3
D3S3T0, RIBL_METSFQ2NHB2, RIBL_METSTO26932, RIBL_METTH
D9PX81, RIBL_METTMA0B7A6, RIBL_METTPD7DTT8, RIBL_METV3
C9RF94, RIBL_METVMA6UNT3, RIBL_METVSD3SYU6, RIBL_NATMM
Q3IQ95, RIBL_NATPDQ6L0A7, RIBL_PICTOQ9UZ37, RIBL_PYRAB
Q8U1T9, RIBL_PYRFUO58466, RIBL_PYRHOQ9HJ34, RIBL_THEAC
C5A1S7, RIBL_THEGJQ5JHT4, RIBL_THEKOB6YXC8, RIBL_THEON
C6A439, RIBL_THESMQ979C2, RIBL_THEVO

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