ENZYME entry: EC 2.7.7.80

Accepted Name
Molybdopterin-synthase adenylyltransferase.
Reaction catalysed
ATP + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly <=> diphosphate + [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP
Comment(s)
  • Adenylates the C-terminus of the small subunit of the molybdopterin synthase.
  • This activation is required to form the thiocarboxylated C-terminus of the active molybdopterin synthase small subunit.
  • The reaction occurs in prokaryotes and eukaryotes.
  • In the human, the reaction is catalyzed by the N-terminal domain of the protein MOCS3, which also includes a molybdopterin-synthase sulfurtransferase (EC 2.8.1.11) C-terminal domain.
  • Formerly EC 2.7.7.n4.
Cross-references
BRENDA2.7.7.80
EC2PDB2.7.7.80
ExplorEnz2.7.7.80
PRIAM enzyme-specific profiles2.7.7.80
KEGG Ligand Database for Enzyme Nomenclature2.7.7.80
IUBMB Enzyme Nomenclature2.7.7.80
IntEnz2.7.7.80
MEDLINEFind literature relating to 2.7.7.80
MetaCyc2.7.7.80
UniProtKB/Swiss-Prot
B5DS72, MOC31_DROPS;  B6TNK6, MOC31_MAIZE;  Q29PG5, MOC32_DROPS;  
B4FAT0, MOC32_MAIZE;  Q17CA7, MOCS3_AEDAE;  Q7PY41, MOCS3_ANOGA;  
Q9ZNW0, MOCS3_ARATH;  A1A4L8, MOCS3_BOVIN;  A8WRE3, MOCS3_CAEBR;  
O44510, MOCS3_CAEEL;  B0W377, MOCS3_CULQU;  Q8AWD2, MOCS3_DANRE;  
B3MLX7, MOCS3_DROAN;  B4JBC4, MOCS3_DROGR;  Q9VLJ8, MOCS3_DROME;  
B4KI53, MOCS3_DROMO;  B4GKQ3, MOCS3_DROPE;  B4HYP0, MOCS3_DROSE;  
B4LRB9, MOCS3_DROVI;  B4N7R4, MOCS3_DROWI;  B4NXF7, MOCS3_DROYA;  
O95396, MOCS3_HUMAN;  A2BDX3, MOCS3_MOUSE;  A3ACF3, MOCS3_ORYSJ;  
A5GFZ6, MOCS3_PIG;  Q58E95, MOCS3_XENLA;  O31702, MOEB_BACSU;  
P12282, MOEB_ECOLI;  Q6B908, MOEB_GRATL;  P45211, MOEB_HAEIN;  
P51335, MOEB_PORPU;  Q1XDF1, MOEB_PYRYE;  Q56067, MOEB_SALTY;  
A1CAZ7, UBA4_ASPCL;  B0Y0P7, UBA4_ASPFC;  Q4WV19, UBA4_ASPFU;  
A2R3H4, UBA4_ASPNC;  Q2TWN3, UBA4_ASPOR;  Q0CFD4, UBA4_ASPTN;  
Q55FS0, UBA4_DICDI;  O59954, UBA4_EMENI;  A4RPM5, UBA4_MAGO7;  
A1DED8, UBA4_NEOFI;  A7F582, UBA4_SCLS1;  

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