ENZYME entry: EC 2.8.1.9
| Accepted Name |
|---|
| Molybdenum cofactor sulfurtransferase.
|
| Alternative Name(s) |
|---|
| MoCo sulfurase. |
| MoCo sulfurtransferase. |
| Molybdenum cofactor sulfurase. |
| Reaction catalysed |
|---|
| Molybdenum cofactor + L-cysteine + 2 H(+) <=> thio-molybdenum cofactor + L-alanine + H(2)O |
| Cofactor(s) |
|---|
| Pyridoxal 5'-phosphate.
|
| Comment(s) |
|---|
- Replaces the equatorial oxo ligand of the molybdenum by sulfur via an
enzyme-bound persulfide.
- The reaction occurs in prokaryotes and eukaryotes but MoCo
sulfurtransferases are only found in eukaryotes.
- In prokaryotes the reaction is catalyzed by two enzymes: EC 2.8.1.7,
which is homologous to the N-terminus of eukaryotic MoCo
sulfurtransferases, and a molybdo-enzyme specific chaperone which
binds the MoCo and acts as an adapter protein.
|
| Cross-references |
|---|
| BRENDA | 2.8.1.9 |
| EC2PDB | 2.8.1.9 |
| ExplorEnz | 2.8.1.9 |
| PRIAM enzyme-specific profiles | 2.8.1.9 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.8.1.9 |
| IUBMB Enzyme Nomenclature | 2.8.1.9 |
| IntEnz | 2.8.1.9 |
| MEDLINE | Find literature relating to 2.8.1.9 |
| MetaCyc | 2.8.1.9 |
| UniProtKB/Swiss-Prot |
| Q16GH0, MOCO1_AEDAE; | B0WSW8, MOCO1_CULQU; | Q16P87, MOCO2_AEDAE; |
| B0WSX1, MOCO2_CULQU; | Q16P90, MOCO3_AEDAE; | Q7QFL7, MOCOS_ANOGA; |
| Q9C5X8, MOCOS_ARATH; | A1CHL0, MOCOS_ASPCL; | B0Y691, MOCOS_ASPFC; |
| Q4WPE6, MOCOS_ASPFU; | A2QIK9, MOCOS_ASPNC; | Q2UH11, MOCOS_ASPOR; |
| Q0CLW8, MOCOS_ASPTN; | Q8IU29, MOCOS_BOMMO; | A6SRX6, MOCOS_BOTFB; |
| Q9N0E7, MOCOS_BOVIN; | A8X493, MOCOS_CAEBR; | Q21657, MOCOS_CAEEL; |
| Q2HE65, MOCOS_CHAGB; | A2VD33, MOCOS_DANRE; | Q559G8, MOCOS_DICDI; |
| B3MZN7, MOCOS_DROAN; | B3NY19, MOCOS_DROER; | B4JXP7, MOCOS_DROGR; |
| Q9VRA2, MOCOS_DROME; | B4L340, MOCOS_DROMO; | B4H0S8, MOCOS_DROPE; |
| Q29GM0, MOCOS_DROPS; | B4M3C9, MOCOS_DROVI; | B4N1V2, MOCOS_DROWI; |
| B4PYH5, MOCOS_DROYA; | Q9UV64, MOCOS_EMENI; | Q96EN8, MOCOS_HUMAN; |
| A4RK48, MOCOS_MAGO7; | Q14CH1, MOCOS_MOUSE; | A1CX75, MOCOS_NEOFI; |
| Q655R6, MOCOS_ORYSJ; | Q8LGM7, MOCOS_SOLLC; |
|
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