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ENZYME entry: EC 2.8.1.9

Accepted Name
Molybdenum cofactor sulfurtransferase.
Alternative Name(s)
MoCo sulfurase.
MoCo sulfurtransferase.
Molybdenum cofactor sulfurase.
Reaction catalysed
Molybdenum cofactor + L-cysteine + reduced acceptor + 2 H(+) <=> thio-molybdenum cofactor + L-alanine + H(2)O + oxidized acceptor
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide.
  • The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes.
  • In prokaryotes the reaction is catalyzed by two enzymes: EC 2.8.1.7, which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.
Cross-references
BRENDA2.8.1.9
EC2PDB2.8.1.9
ExplorEnz2.8.1.9
PRIAM enzyme-specific profiles2.8.1.9
KEGG Ligand Database for Enzyme Nomenclature2.8.1.9
IUBMB Enzyme Nomenclature2.8.1.9
IntEnz2.8.1.9
MEDLINEFind literature relating to 2.8.1.9
MetaCyc2.8.1.9
UniProtKB/Swiss-Prot
Q16GH0, MOCO1_AEDAE;  B0WSW8, MOCO1_CULQU;  Q16P87, MOCO2_AEDAE;  
B0WSX1, MOCO2_CULQU;  Q16P90, MOCO3_AEDAE;  Q7QFL7, MOCOS_ANOGA;  
Q9C5X8, MOCOS_ARATH;  A1CHL0, MOCOS_ASPCL;  B0Y691, MOCOS_ASPFC;  
Q4WPE6, MOCOS_ASPFU;  A2QIK9, MOCOS_ASPNC;  Q2UH11, MOCOS_ASPOR;  
Q0CLW8, MOCOS_ASPTN;  Q8IU29, MOCOS_BOMMO;  A6SRX6, MOCOS_BOTFB;  
Q9N0E7, MOCOS_BOVIN;  A8X493, MOCOS_CAEBR;  Q21657, MOCOS_CAEEL;  
Q2HE65, MOCOS_CHAGB;  A2VD33, MOCOS_DANRE;  Q559G8, MOCOS_DICDI;  
B3MZN7, MOCOS_DROAN;  B3NY19, MOCOS_DROER;  B4JXP7, MOCOS_DROGR;  
Q9VRA2, MOCOS_DROME;  B4L340, MOCOS_DROMO;  B4H0S8, MOCOS_DROPE;  
Q29GM0, MOCOS_DROPS;  B4M3C9, MOCOS_DROVI;  B4N1V2, MOCOS_DROWI;  
B4PYH5, MOCOS_DROYA;  Q9UV64, MOCOS_EMENI;  Q96EN8, MOCOS_HUMAN;  
A4RK48, MOCOS_MAGO7;  Q14CH1, MOCOS_MOUSE;  A1CX75, MOCOS_NEOFI;  
Q7SE17, MOCOS_NEUCR;  Q655R6, MOCOS_ORYSJ;  Q8LGM7, MOCOS_SOLLC;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-