ENZYME

ENZYME entry: EC 2.8.2.14

Accepted Name

Bile-salt sulfotransferase.

Alternative Name(s)

BAST I.

Bile acid sulfotransferase I.

Bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase.

Bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase.

Glycolithocholate sulfotransferase.

Reaction catalysed

3'-phosphoadenylyl sulfate + glycolithocholate <=> adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate
3'-phosphoadenylyl sulfate + taurolithocholate <=> adenosine 3',5'-bisphosphate + taurolithocholate sulfate

Comment(s)

The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species.
This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase.
In addition to the 5-beta-bile acid glycolithocholate, deoxycholate, 3-beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3-beta- hydroxyandrost-5-en-17-one) also act as substrates (see also EC 2.8.2.2 and EC 2.8.2.34).
May be identical to EC 2.8.2.2.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature