ENZYME entry: EC 2.8.2.31

Accepted Name
Petromyzonol sulfotransferase.
Alternative Name(s)
PZ-SULT.
Reaction catalysed
3'-phosphoadenylyl sulfate + 5-alpha-cholan-3-alpha,7-alpha,12-alpha,24-tetrol <=> adenosine 3',5'-bisphosphate + 5-alpha-cholan-3-alpha,7-alpha,12-alpha-triol 24-sulfate
Comment(s)
  • The enzyme from the lamprey Petromyzon marinus can also use the corresponding 3-ketone as a substrate.
  • It is stereoselective (5-alpha-cholane) and regioselective, exhibiting a preference for an hydroxy group at C-24.
  • The enzyme is inactive when allocholic acid, which has a carboxy group at C-24, is used as a substrate.
Cross-references
BRENDA2.8.2.31
EC2PDB2.8.2.31
ExplorEnz2.8.2.31
PRIAM enzyme-specific profiles2.8.2.31
KEGG Ligand Database for Enzyme Nomenclature2.8.2.31
IUBMB Enzyme Nomenclature2.8.2.31
IntEnz2.8.2.31
MEDLINEFind literature relating to 2.8.2.31
MetaCyc2.8.2.31

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