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ENZYME

ENZYME entry: EC 2.8.4.1

PURL: https://purl.expasy.org/enzyme/EC/2.8.4.1
Accepted Name
coenzyme-B sulfoethylthiotransferase
Alternative Name(s)
methyl coenzyme M reductase
methyl-CoM reductase
Reaction catalysed
coenzyme B + methyl-coenzyme M = methane + coenzyme M-coenzyme B heterodisulfide
Comment(s)
  • This enzyme catalyzes the final step in methanogenesis, the biological production of methane.
  • This important anaerobic process is carried out only by methanogenic archaea.
  • The enzyme can also function in reverse, for anaerobic oxidation of methane.
  • The enzyme requires the hydroporphinoid nickel complex coenzyme F430.
  • Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates.
  • The sulfide sulfur can be replaced by selenium but not by oxygen.
Cross-references
BRENDA2.8.4.1
EC2PDB2.8.4.1
ExplorEnz2.8.4.1
KEGG Ligand Database for Enzyme Nomenclature2.8.4.1
IUBMB Enzyme Nomenclature2.8.4.1
MEDLINEFind literature relating to 2.8.4.1
MetaCyc2.8.4.1
Rhea expert-curated reactions2.8.4.1
UniProtKB/Swiss-Prot
Q8THH1, MCRA_METACP07962, MCRA_METBFP12971, MCRA_METFE
Q58256, MCRA_METJAQ49605, MCRA_METKAP22948, MCRA_METTE
O27232, MCRA_METTHP11558, MCRA_METTMP07961, MCRA_METVA
P11559, MCRA_METVOP07955, MCRB_METBFP12972, MCRB_METFE
Q58252, MCRB_METJAP22949, MCRB_METTEO27236, MCRB_METTH
P11560, MCRB_METTMP07956, MCRB_METVAP11561, MCRB_METVO
P07964, MCRG_METBFP12973, MCRG_METFEQ58255, MCRG_METJA
P22950, MCRG_METTEO27233, MCRG_METTHP11562, MCRG_METTM
P07963, MCRG_METVAP11563, MCRG_METVOQ49174, MCRX_METFV
Q60391, MCRX_METJAP21110, MCRX_METTHP58815, MCRX_METTM
Q49171, MCRY_METFVQ60390, MCRY_METJAP21111, MCRY_METTH
D9PXZ6, MCRY_METTMQ49173, MCRZ_METFVQ60387, MCRZ_METJA
P21112, MCRZ_METTHP58816, MCRZ_METTM

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