ENZYME entry: EC 3.1.1.51

Accepted Name
Phorbol-diester hydrolase.
Alternative Name(s)
Diacylphorbate 12-hydrolase.
Reaction catalysed
Phorbol 12,13-dibutanoate + H(2)O <=> phorbol 13-butanoate + butanoate
Comment(s)
  • Hydrolyzes the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid).
  • This reaction inactivates tumor promoter 12-O-tetradecanoylphorbol- 13-acetate from croton oil.
Cross-references
BRENDA3.1.1.51
EC2PDB3.1.1.51
ExplorEnz3.1.1.51
PRIAM enzyme-specific profiles3.1.1.51
KEGG Ligand Database for Enzyme Nomenclature3.1.1.51
IUBMB Enzyme Nomenclature3.1.1.51
IntEnz3.1.1.51
MEDLINEFind literature relating to 3.1.1.51
MetaCyc3.1.1.51

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