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ENZYME

ENZYME entry: EC 3.1.1.51

Accepted Name
phorbol-diester hydrolase
Alternative Name(s)
diacylphorbate 12-hydrolase
Reaction catalysed
H2O + phorbol 12,13-dibutanoate <=> butanoate + H(+) + phorbol 13-butanoate
Comment(s)
  • Hydrolyzes the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid).
  • This reaction inactivates tumor promoter 12-O-tetradecanoylphorbol- 13-acetate from croton oil.
Cross-references
BRENDA3.1.1.51
EC2PDB3.1.1.51
ExplorEnz3.1.1.51
PRIAM enzyme-specific profiles3.1.1.51
KEGG Ligand Database for Enzyme Nomenclature3.1.1.51
IUBMB Enzyme Nomenclature3.1.1.51
IntEnz3.1.1.51
MEDLINEFind literature relating to 3.1.1.51
MetaCyc3.1.1.51
Rhea expert-curated reactions3.1.1.51

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-