ENZYME entry: EC 3.1.1.79

Accepted Name
Hormone-sensitive lipase.
Alternative Name(s)
HSL.
Reaction catalysed
  • Diacylglycerol + H(2)O <=> monoacylglycerol + a carboxylate
  • Triacylglycerol + H(2)O <=> diacylglycerol + a carboxylate
  • Monoacylglycerol + H(2)O <=> glycerol + a carboxylate
Comment(s)
  • This enzyme is a serine hydrolase.
  • Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity.
  • It hydrolyzes all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) as well as cholesteryl esters, steroid fatty acid esters, retinyl esters and p-nitrophenyl esters.
  • It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond.
  • The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length.
  • The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
Cross-references
PROSITEPDOC00903
BRENDA3.1.1.79
EC2PDB3.1.1.79
ExplorEnz3.1.1.79
PRIAM enzyme-specific profiles3.1.1.79
KEGG Ligand Database for Enzyme Nomenclature3.1.1.79
IUBMB Enzyme Nomenclature3.1.1.79
IntEnz3.1.1.79
MEDLINEFind literature relating to 3.1.1.79
MetaCyc3.1.1.79
UniProtKB/Swiss-Prot
P16386, LIPS_BOVIN;  Q05469, LIPS_HUMAN;  P54310, LIPS_MOUSE;  
Q68J42, LIPS_PIG;  P15304, LIPS_RAT;  Q9R101, LIPS_SPETR;  

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