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ENZYME entry: EC

Accepted Name
Quorum-quenching N-acyl-homoserine lactonase.
Alternative Name(s)
Acyl homoserine degrading enzyme.
Acyl-homoserine-lactone acylase.
AHL lactonase.
AHL-degrading enzyme.
AHL-inactivating enzyme.
N-acyl homoserine lactonase.
N-acyl homoserine lactone hydrolase.
N-acyl-homoserine lactone lactonase.
N-acyl-L-homoserine lactone hydrolase.
Quorum-quenching lactonase.
Quorum-quenching N-acyl homoserine lactone hydrolase.
Reaction catalysed
An N-acyl-L-homoserine lactone + H(2)O <=> an N-acyl-L-homoserine
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria.
  • N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
PRIAM enzyme-specific profiles3.1.1.81
KEGG Ligand Database for Enzyme Nomenclature3.1.1.81
IUBMB Enzyme Nomenclature3.1.1.81
MEDLINEFind literature relating to
P52430, PON1_MOUSE;  P27170, PON1_RABIT;  P55159, PON1_RAT;  
Q58DS7, PON2_BOVIN;  P54832, PON2_CANLF;  Q15165, PON2_HUMAN;  
Q62086, PON2_MOUSE;  Q6AXM8, PON2_RAT;  Q15166, PON3_HUMAN;  
Q62087, PON3_MOUSE;  Q9BGN0, PON3_RABIT;  Q68FP2, PON3_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
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