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ENZYME entry: EC 126.96.36.199
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|Quorum-quenching N-acyl-homoserine lactonase.
|Acyl homoserine degrading enzyme.|
|N-acyl homoserine lactonase.|
|N-acyl homoserine lactone hydrolase.|
|N-acyl-homoserine lactone lactonase.|
|N-acyl-L-homoserine lactone hydrolase.|
|Quorum-quenching N-acyl homoserine lactone hydrolase.|
|An N-acyl-L-homoserine lactone + H(2)O <=> an N-acyl-L-homoserine|
- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial
species and are used by them to regulate the expression of virulence
genes in a process known as quorum-sensing.
- Each bacterial cell has a basal level of AHL and, once the population
density reaches a critical level, it triggers AHL-signaling which,
in turn, initiates the expression of particular virulence genes.
- Plants or animals capable of degrading AHLs would have a therapeutic
advantage in avoiding bacterial infection as they could prevent AHL-
signaling and the expression of virulence genes in quorum-sensing
- N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L-
homoserine lactone, N-butanoyl-L-homoserine lactone and
N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
|P0CJ63, AHLLA_BACTK; ||A9CKY2, AHLLB_AGRFC; ||B9JPK6, AHLLB_AGRRK; |
|Q7D3U0, AHLLM_AGRFC; ||A8IQD2, AHLLM_AZOC5; ||Q1M813, AHLLM_RHIL3; |
|Q8VPD5, AHLLM_RHIRD; ||Q7X3T2, AHLL_ARTSP; ||Q08GP4, AHLL_BACCE; |
|Q9L8R8, AHLL_BACSP; ||Q7B8C3, AHLL_BACT3; ||Q7B8C5, AHLL_BACTA; |
|A3FJ64, AHLL_BACTU; ||C6L862, AHLL_MICTS; ||P27169, PON1_HUMAN; |
|P52430, PON1_MOUSE; ||P27170, PON1_RABIT; ||P55159, PON1_RAT; |
|Q58DS7, PON2_BOVIN; ||P54832, PON2_CANLF; ||Q15165, PON2_HUMAN; |
|Q62086, PON2_MOUSE; ||Q6AXM8, PON2_RAT; ||Q15166, PON3_HUMAN; |
|Q62087, PON3_MOUSE; ||Q9BGN0, PON3_RABIT; ||Q68FP2, PON3_RAT; |
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