ENZYME entry: EC 3.1.1.81
| Accepted Name |
|---|
| Quorum-quenching N-acyl-homoserine lactonase.
|
| Alternative Name(s) |
|---|
| Acyl homoserine degrading enzyme. |
| Acyl-homoserine-lactone acylase. |
| AHL lactonase. |
| AHL-degrading enzyme. |
| AHL-inactivating enzyme. |
| AHLase. |
| N-acyl homoserine lactonase. |
| N-acyl homoserine lactone hydrolase. |
| N-acyl-homoserine lactone lactonase. |
| N-acyl-L-homoserine lactone hydrolase. |
| Quorum-quenching lactonase. |
| Quorum-quenching N-acyl homoserine lactone hydrolase. |
| Reaction catalysed |
|---|
| An N-acyl-L-homoserine lactone + H(2)O <=> an N-acyl-L-homoserine |
| Comment(s) |
|---|
- Acyl-homoserine lactones (AHLs) are produced by a number of bacterial
species and are used by them to regulate the expression of virulence
genes in a process known as quorum-sensing.
- Each bacterial cell has a basal level of AHL and, once the population
density reaches a critical level, it triggers AHL-signaling which,
in turn, initiates the expression of particular virulence genes.
- Plants or animals capable of degrading AHLs would have a therapeutic
advantage in avoiding bacterial infection as they could prevent AHL-
signaling and the expression of virulence genes in quorum-sensing
bacteria.
- N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L-
homoserine lactone, N-butanoyl-L-homoserine lactone and
N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
|
| Cross-references |
|---|
| BRENDA | 3.1.1.81 |
| EC2PDB | 3.1.1.81 |
| ExplorEnz | 3.1.1.81 |
| PRIAM enzyme-specific profiles | 3.1.1.81 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.1.81 |
| IUBMB Enzyme Nomenclature | 3.1.1.81 |
| IntEnz | 3.1.1.81 |
| MEDLINE | Find literature relating to 3.1.1.81 |
| MetaCyc | 3.1.1.81 |
| UniProtKB/Swiss-Prot |
| P0CJ63, AHLLA_BACTK; | B9JPK6, AHLLB_AGRRK; | A9CKY2, AHLLB_AGRT5; |
| Q7D3U0, AHLLM_AGRT5; | A8IQD2, AHLLM_AZOC5; | Q1M813, AHLLM_RHIL3; |
| Q8VPD5, AHLLM_RHIRD; | Q7X3T2, AHLL_ARTSP; | Q08GP4, AHLL_BACCE; |
| Q9L8R8, AHLL_BACSP; | Q7B8C3, AHLL_BACT3; | Q7B8C5, AHLL_BACTA; |
| A3FJ64, AHLL_BACTU; | C6L862, AHLL_MICTS; | P27169, PON1_HUMAN; |
| P52430, PON1_MOUSE; | P27170, PON1_RABIT; | P55159, PON1_RAT; |
| Q58DS7, PON2_BOVIN; | P54832, PON2_CANFA; | Q15165, PON2_HUMAN; |
| Q62086, PON2_MOUSE; | Q6AXM8, PON2_RAT; | Q15166, PON3_HUMAN; |
| Q62087, PON3_MOUSE; | Q9BGN0, PON3_RABIT; | Q68FP2, PON3_RAT; |
|
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