ENZYME entry: EC 3.1.1.81

Accepted Name
Quorum-quenching N-acyl-homoserine lactonase.
Alternative Name(s)
Acyl homoserine degrading enzyme.
Acyl-homoserine-lactone acylase.
AHL lactonase.
AHL-degrading enzyme.
AHL-inactivating enzyme.
AHLase.
N-acyl homoserine lactonase.
N-acyl homoserine lactone hydrolase.
N-acyl-homoserine lactone lactonase.
N-acyl-L-homoserine lactone hydrolase.
Quorum-quenching lactonase.
Quorum-quenching N-acyl homoserine lactone hydrolase.
Reaction catalysed
An N-acyl-L-homoserine lactone + H(2)O <=> an N-acyl-L-homoserine
Comment(s)
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL- signaling and the expression of virulence genes in quorum-sensing bacteria.
  • N-(3-oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L- homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates.
Cross-references
BRENDA3.1.1.81
EC2PDB3.1.1.81
ExplorEnz3.1.1.81
PRIAM enzyme-specific profiles3.1.1.81
KEGG Ligand Database for Enzyme Nomenclature3.1.1.81
IUBMB Enzyme Nomenclature3.1.1.81
IntEnz3.1.1.81
MEDLINEFind literature relating to 3.1.1.81
MetaCyc3.1.1.81
UniProtKB/Swiss-Prot
P0CJ63, AHLLA_BACTK;  A9CKY2, AHLLB_AGRFC;  B9JPK6, AHLLB_AGRRK;  
Q7D3U0, AHLLM_AGRFC;  A8IQD2, AHLLM_AZOC5;  Q1M813, AHLLM_RHIL3;  
Q8VPD5, AHLLM_RHIRD;  Q7X3T2, AHLL_ARTSP;  Q08GP4, AHLL_BACCE;  
Q9L8R8, AHLL_BACSP;  Q7B8C3, AHLL_BACT3;  Q7B8C5, AHLL_BACTA;  
A3FJ64, AHLL_BACTU;  C6L862, AHLL_MICTS;  P27169, PON1_HUMAN;  
P52430, PON1_MOUSE;  P27170, PON1_RABIT;  P55159, PON1_RAT;  
Q58DS7, PON2_BOVIN;  P54832, PON2_CANLF;  Q15165, PON2_HUMAN;  
Q62086, PON2_MOUSE;  Q6AXM8, PON2_RAT;  Q15166, PON3_HUMAN;  
Q62087, PON3_MOUSE;  Q9BGN0, PON3_RABIT;  Q68FP2, PON3_RAT;  

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