ENZYME entry: EC 3.1.26.13

Accepted Name
Retroviral ribonuclease H.
Reaction catalysed
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus
Comment(s)
  • Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication.
  • To perform this task the enzyme combines two distinct activities.
  • The polymerase domain (EC 2.7.7.49) occupies the N-terminal two- thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third.
  • The RNase H domain of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites.
Cross-references
BRENDA3.1.26.13
EC2PDB3.1.26.13
ExplorEnz3.1.26.13
PRIAM enzyme-specific profiles3.1.26.13
KEGG Ligand Database for Enzyme Nomenclature3.1.26.13
IUBMB Enzyme Nomenclature3.1.26.13
IntEnz3.1.26.13
MEDLINEFind literature relating to 3.1.26.13
MetaCyc3.1.26.13
UniProtKB/Swiss-Prot
P19560, POL_BIV29;  P33459, POL_CAEVC;  P11204, POL_EIAV9;  
P32542, POL_EIAVC;  P03371, POL_EIAVY;  P16088, POL_FIVPE;  
P19028, POL_FIVSD;  P31822, POL_FIVT2;  O93215, POL_HV190;  
O12158, POL_HV192;  O89290, POL_HV193;  Q9QBY3, POL_HV196;  
Q9QBZ9, POL_HV197;  O41798, POL_HV19N;  P03369, POL_HV1A2;  
Q77373, POL_HV1AN;  P03366, POL_HV1B1;  P04587, POL_HV1B5;  
Q73368, POL_HV1B9;  P03367, POL_HV1BR;  P04589, POL_HV1EL;  
Q75002, POL_HV1ET;  P04585, POL_HV1H2;  P20875, POL_HV1JR;  
P0C6F2, POL_HV1LW;  Q9QBZ1, POL_HV1M2;  P04588, POL_HV1MA;  
P05961, POL_HV1MN;  Q9QBZ5, POL_HV1MP;  Q79666, POL_HV1MV;  
P12497, POL_HV1N5;  P18802, POL_HV1ND;  P20892, POL_HV1OY;  
P05959, POL_HV1RH;  Q9WC54, POL_HV1S2;  Q9WC63, POL_HV1S9;  
O89940, POL_HV1SE;  P24740, POL_HV1U4;  Q9Q720, POL_HV1V9;  
Q9QSR3, POL_HV1VI;  P35963, POL_HV1Y2;  Q9IDV9, POL_HV1YB;  
O91080, POL_HV1YF;  P12499, POL_HV1Z2;  P18096, POL_HV2BE;  
P24107, POL_HV2CA;  P17757, POL_HV2D1;  P15833, POL_HV2D2;  
Q89928, POL_HV2EH;  P18042, POL_HV2G1;  Q74120, POL_HV2KR;  
P05962, POL_HV2NZ;  P04584, POL_HV2RO;  P12451, POL_HV2SB;  
P20876, POL_HV2ST;  Q76634, POL_HV2UC;  Q82851, POL_JEMBR;  
P16901, POL_OMVVS;  P17283, POL_SIVCZ;  Q1A249, POL_SIVEK;  
Q02836, POL_SIVG1;  P22382, POL_SIVGB;  P05896, POL_SIVM1;  
Q1A267, POL_SIVMB;  P05897, POL_SIVMK;  P12502, POL_SIVS4;  
P19505, POL_SIVSP;  Q8AII1, POL_SIVTN;  P27973, POL_SIVV1;  
P27980, POL_SIVVG;  P05895, POL_SIVVT;  P03370, POL_VILV;  
P23426, POL_VILV1;  P23427, POL_VILV2;  P35956, POL_VILVK;  

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