ENZYME entry: EC 3.1.3.1

Accepted Name
Alkaline phosphatase.
Alternative Name(s)
Alkaline phosphomonoesterase.
Glycerophosphatase.
Phosphomonoesterase.
Reaction catalysed
A phosphate monoester + H(2)O <=> an alcohol + phosphate
Cofactor(s)
Magnesium; Zinc.
Comment(s)
  • Active at a high pH optimum.
  • Wide specificity.
  • Also catalyzes transphosphorylations.
  • Some enzymes hydrolase diphosphate (cf. EC 3.6.1.1).
Cross-references
PROSITEPDOC00113
BRENDA3.1.3.1
EC2PDB3.1.3.1
ExplorEnz3.1.3.1
PRIAM enzyme-specific profiles3.1.3.1
KEGG Ligand Database for Enzyme Nomenclature3.1.3.1
IUBMB Enzyme Nomenclature3.1.3.1
IntEnz3.1.3.1
MEDLINEFind literature relating to 3.1.3.1
MetaCyc3.1.3.1
UniProtKB/Swiss-Prot
P86348, ALPH_DEIAC;  Q9KJX5, ALPH_ELIME;  A1YYW7, ALPH_SPHSX;  
Q55320, ALPH_SYNE7;  Q5NNZ8, ALPH_ZYMMO;  Q24238, APH4_DROME;  
P05187, PPB1_HUMAN;  P81800, PPB1_PREIN;  P19405, PPB3_BACSU;  
P19406, PPB4_BACSU;  P42251, PPBD_BACSU;  P35483, PPBH_PSEAE;  
P15693, PPBI1_RAT;  P51740, PPBI2_RAT;  P19111, PPBI_BOVIN;  
P09923, PPBI_HUMAN;  P24822, PPBI_MOUSE;  P35482, PPBL_PSEAE;  
P10696, PPBN_HUMAN;  P24823, PPBN_MOUSE;  P09487, PPBT_BOVIN;  
Q92058, PPBT_CHICK;  Q29486, PPBT_FELCA;  P05186, PPBT_HUMAN;  
P09242, PPBT_MOUSE;  P08289, PPBT_RAT;  P29523, PPB_BOMMO;  
P00634, PPB_ECOLI;  P21948, PPB_ESCF3;  P83456, PPB_GADMO;  
Q05205, PPB_LYSEN;  O60109, PPB_SCHPO;  P19147, PPB_SERMA;  
P11491, PPB_YEAST;  

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