ENZYME entry: EC 3.1.3.4

Accepted Name
Phosphatidate phosphatase.
Alternative Name(s)
Lipin.
Phosphatic acid phosphatase.
Phosphatic acid phosphohydrolase.
Phosphatidic acid phosphatase.
Reaction catalysed
A 1,2-diacylglycerol 3-phosphate + H(2)O <=> a 1,2-diacyl-sn-glycerol + phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • This enzyme catalyzes the Mg(2+)-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol.
  • In lipid signaling, the enzyme generates a pool of DAG to be used for protein kinase C activation.
  • The mammalian enzymes are known as lipins.
Cross-references
BRENDA3.1.3.4
EC2PDB3.1.3.4
ExplorEnz3.1.3.4
PRIAM enzyme-specific profiles3.1.3.4
KEGG Ligand Database for Enzyme Nomenclature3.1.3.4
IUBMB Enzyme Nomenclature3.1.3.4
IntEnz3.1.3.4
MEDLINEFind literature relating to 3.1.3.4
MetaCyc3.1.3.4
UniProtKB/Swiss-Prot
P53933, APP1_YEAST;  Q9UUA6, DPP1_SCHPO;  Q05521, DPP1_YEAST;  
Q14693, LPIN1_HUMAN;  Q91ZP3, LPIN1_MOUSE;  Q92539, LPIN2_HUMAN;  
Q99PI5, LPIN2_MOUSE;  Q9BQK8, LPIN3_HUMAN;  Q99PI4, LPIN3_MOUSE;  
Q7TNN8, LPIN3_MUSSP;  Q04396, LPP1_YEAST;  Q9SF47, PAH1_ARATH;  
P32567, PAH1_YEAST;  Q9FMN2, PAH2_ARATH;  P0A925, PGPB_ECO57;  
P0A924, PGPB_ECOLI;  P44570, PGPB_HAEIN;  P0A926, PGPB_SHIFL;  
O88956, PLPP1_CAVPO;  O14494, PLPP1_HUMAN;  Q61469, PLPP1_MOUSE;  
P60588, PLPP1_PIG;  O08564, PLPP1_RAT;  Q2HJ61, PLPP2_BOVIN;  
O43688, PLPP2_HUMAN;  Q9DAX2, PLPP2_MOUSE;  Q8K593, PLPP2_RAT;  
Q3SZE3, PLPP3_BOVIN;  O14495, PLPP3_HUMAN;  Q99JY8, PLPP3_MOUSE;  
P97544, PLPP3_RAT;  Q5VZY2, PLPP4_HUMAN;  Q0VBU9, PLPP4_MOUSE;  
Q8NEB5, PLPP5_HUMAN;  Q3UMZ3, PLPP5_MOUSE;  Q6GQ62, PLPP5_XENLA;  
Q29RT8, PLPR2_BOVIN;  Q96GM1, PLPR2_HUMAN;  Q8VCY8, PLPR2_MOUSE;  
Q6W5G4, PLPR2_RAT;  Q6T4P5, PLPR3_HUMAN;  Q7TPB0, PLPR3_MOUSE;  
Q7TMB0, PLPR3_RAT;  Q7Z2D5, PLPR4_HUMAN;  Q7TME0, PLPR4_MOUSE;  
Q7TMB7, PLPR4_RAT;  Q9V576, WUN_DROME;  

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