ENZYME entry: EC 3.1.3.4

Accepted Name
Phosphatidate phosphatase.
Alternative Name(s)
Lipin.
Phosphatic acid phosphatase.
Phosphatic acid phosphohydrolase.
Phosphatidic acid phospphatase.
Reaction catalysed
A 1,2-diacylglycerol 3-phosphate + H(2)O <=> a 1,2-diacyl-sn-glycerol + phosphate
Cofactor(s)
Magnesium.
Comment(s)
  • This enzyme catalyzes the Mg(2+)-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol.
  • In lipid signaling, the enzyme generates a pool of DAG to be used for protein kinase C activation.
  • The mammalian enzymes are known as lipins.
Cross-references
BRENDA3.1.3.4
EC2PDB3.1.3.4
ExplorEnz3.1.3.4
PRIAM enzyme-specific profiles3.1.3.4
KEGG Ligand Database for Enzyme Nomenclature3.1.3.4
IUBMB Enzyme Nomenclature3.1.3.4
IntEnz3.1.3.4
MEDLINEFind literature relating to 3.1.3.4
MetaCyc3.1.3.4
UniProtKB/Swiss-Prot
P53933, APP1_YEAST;  Q9UUA6, DPP1_SCHPO;  Q05521, DPP1_YEAST;  
Q14693, LPIN1_HUMAN;  Q91ZP3, LPIN1_MOUSE;  Q92539, LPIN2_HUMAN;  
Q99PI5, LPIN2_MOUSE;  Q9BQK8, LPIN3_HUMAN;  Q99PI4, LPIN3_MOUSE;  
Q7TNN8, LPIN3_MUSSP;  O88956, LPP1_CAVPO;  O14494, LPP1_HUMAN;  
Q61469, LPP1_MOUSE;  P60588, LPP1_PIG;  O08564, LPP1_RAT;  
Q04396, LPP1_YEAST;  Q2HJ61, LPP2_BOVIN;  O43688, LPP2_HUMAN;  
Q9DAX2, LPP2_MOUSE;  Q8K593, LPP2_RAT;  Q3SZE3, LPP3_BOVIN;  
O14495, LPP3_HUMAN;  Q99JY8, LPP3_MOUSE;  P97544, LPP3_RAT;  
Q29RT8, LPPR2_BOVIN;  Q96GM1, LPPR2_HUMAN;  Q8VCY8, LPPR2_MOUSE;  
Q6W5G4, LPPR2_RAT;  Q6T4P5, LPPR3_HUMAN;  Q7TPB0, LPPR3_MOUSE;  
Q7TMB0, LPPR3_RAT;  Q7Z2D5, LPPR4_HUMAN;  Q7TME0, LPPR4_MOUSE;  
Q7TMB7, LPPR4_RAT;  Q9SF47, PAH1_ARATH;  P32567, PAH1_YEAST;  
Q9FMN2, PAH2_ARATH;  P0A925, PGPB_ECO57;  P0A924, PGPB_ECOLI;  
P44570, PGPB_HAEIN;  P0A926, PGPB_SHIFL;  Q5VZY2, PPC1A_HUMAN;  
Q0VBU9, PPC1A_MOUSE;  Q8NEB5, PPC1B_HUMAN;  Q3UMZ3, PPC1B_MOUSE;  
Q6GQ62, PPC1B_XENLA;  Q9V576, WUN_DROME;  

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