ENZYME entry: EC 3.1.3.67
| Accepted Name |
|---|
| Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
|
| Alternative Name(s) |
|---|
| Phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase. |
| Reaction catalysed |
|---|
| Phosphatidylinositol 3,4,5-trisphosphate + H(2)O <=> phosphatidylinositol 4,5-bisphosphate + phosphate |
| Cofactor(s) |
|---|
| Magnesium.
|
| Comment(s) |
|---|
- Does not dephosphorylate inositol 4,5-bisphosphate.
- This enzyme still works when the 2,3-bis(acyloxy)propyl group is
removed, i.e., it hydrolyzes Ins(1,3,4,5)P(4) to Ins(1,4,5)P(3).
|
| Cross-references |
|---|
| BRENDA | 3.1.3.67 |
| EC2PDB | 3.1.3.67 |
| ExplorEnz | 3.1.3.67 |
| PRIAM enzyme-specific profiles | 3.1.3.67 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.1.3.67 |
| IUBMB Enzyme Nomenclature | 3.1.3.67 |
| IntEnz | 3.1.3.67 |
| MEDLINE | Find literature relating to 3.1.3.67 |
| MetaCyc | 3.1.3.67 |
| UniProtKB/Swiss-Prot |
| Q54JL7, CNRN_DICDI; | P60483, PTEN_CANFA; | Q8T9S7, PTEN_DICDI; |
| P60484, PTEN_HUMAN; | O08586, PTEN_MOUSE; | O94526, PTEN_SCHPO; |
| Q9PUT6, PTEN_XENLA; | P53916, TEP1_YEAST; | Q6XPS3, TPTE2_HUMAN; |
| Q4R6N0, TPTE2_MACFA; |
|
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