ENZYME entry: EC 3.1.3.74

Accepted Name
Pyridoxal phosphatase.
Alternative Name(s)
PLP phosphatase.
PNP phosphatase.
Vitamin B(6) (pyridoxine) phosphatase.
Vitamin B(6)-phosphate phosphatase.
Vitamin B6 (pyridoxine) phosphatase.
Vitamin B6-phosphate phosphatase.
Reaction catalysed
Pyridoxal 5'-phosphate + H(2)O <=> pyridoxal + phosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • Specific for phosphorylated vitamin B(6) compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate.
  • This reaction can also be carried out by EC 3.1.3.1 and EC 3.1.3.2, but these enzymes have very broad substrate specificities.
Cross-references
BRENDA3.1.3.74
EC2PDB3.1.3.74
ExplorEnz3.1.3.74
PRIAM enzyme-specific profiles3.1.3.74
KEGG Ligand Database for Enzyme Nomenclature3.1.3.74
IUBMB Enzyme Nomenclature3.1.3.74
IntEnz3.1.3.74
MEDLINEFind literature relating to 3.1.3.74
MetaCyc3.1.3.74
UniProtKB/Swiss-Prot
Q2KI06, PHOP2_BOVIN;  Q8TCD6, PHOP2_HUMAN;  Q9D9M5, PHOP2_MOUSE;  
Q66HC4, PHOP2_RAT;  Q3ZBF9, PLPP_BOVIN;  Q96GD0, PLPP_HUMAN;  
P60487, PLPP_MOUSE;  Q8VD52, PLPP_RAT;  P21829, YBHA_ECOLI;  
Q8X8L6, YIGL_ECO57;  P27848, YIGL_ECOLI;  

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