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ENZYME

ENZYME entry: EC 3.1.3.86

Accepted Name
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Alternative Name(s)
SHIP
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O <=> a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
Comment(s)
  • This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways.
  • The enzyme also shows activity toward PtdIns(1,3,4,5)P4.
  • The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
  • Formerly EC 3.1.3.n1.
Cross-references
BRENDA3.1.3.86
EC2PDB3.1.3.86
ExplorEnz3.1.3.86
PRIAM enzyme-specific profiles3.1.3.86
KEGG Ligand Database for Enzyme Nomenclature3.1.3.86
IUBMB Enzyme Nomenclature3.1.3.86
IntEnz3.1.3.86
MEDLINEFind literature relating to 3.1.3.86
MetaCyc3.1.3.86
Rhea expert-curated reactions3.1.3.86
UniProtKB/Swiss-Prot
Q92562, FIG4_HUMANQ91WF7, FIG4_MOUSEQ9NRR6, INP5E_HUMAN
Q9JII1, INP5E_MOUSEA0FI79, INP5E_PANTRQ9WVR1, INP5E_RAT
Q9BT40, INP5K_HUMANQ8C5L6, INP5K_MOUSEQ8H0Z6, IP5P3_ARATH
Q9LR47, IP5P6_ARATHQ0WQ41, IP5P7_ARATHQ9SIS4, IP5P9_ARATH
Q5EAF2, IP5PB_ARATHQ9SKB7, IP5PE_ARATHQ84W55, IP5PF_ARATH
Q01968, OCRL_HUMANQ6NVF0, OCRL_MOUSED3ZGS3, OCRL_RAT
Q92835, SHIP1_HUMANQ9ES52, SHIP1_MOUSEP97573, SHIP1_RAT
Q6P4S2, SHIP1_XENLAA0A8I3NFE2, SHIP2_CANLFO15357, SHIP2_HUMAN
Q6P549, SHIP2_MOUSED7PF45, SHIP2_PIGQ9WVR3, SHIP2_RAT
Q2I6J1, SHP2A_DANREQ2I6J0, SHP2B_DANRE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-