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ENZYME entry: EC 188.8.131.52
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|1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O <=> 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate|
- This enzyme hydrolyzes phosphatidylinositol-3,4,5-trisphosphate
(PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), thereby negatively
regulating the PI3K (phosphoinositide 3-kinase) pathways.
- The enzyme also shows activity toward PtdIns(1,3,4,5)P(4).
- The enzyme is involved in several signal transduction pathways in the
immune system leading to an adverse range of effects.
- Formerly EC 3.1.3.n1.
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
|Q8H0Z6, IP5P3_ARATH; ||Q9LR47, IP5P6_ARATH; ||Q0WQ41, IP5P7_ARATH; |
|Q9SIS4, IP5P9_ARATH; ||Q5EAF2, IP5PB_ARATH; ||Q9SKB7, IP5PE_ARATH; |
|Q84W55, IP5PF_ARATH; ||Q92835, SHIP1_HUMAN; ||Q9ES52, SHIP1_MOUSE; |
|P97573, SHIP1_RAT; ||Q6P4S2, SHIP1_XENLA; ||O15357, SHIP2_HUMAN; |
|Q6P549, SHIP2_MOUSE; ||Q9WVR3, SHIP2_RAT; ||Q2I6J1, SHP2A_DANRE; |
|Q2I6J0, SHP2B_DANRE; |
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entries corresponding to 3.1.3.-
entries corresponding to 3.1.-.-
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