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ENZYME entry: EC

Accepted Name
UDP-N-acetylglucosamine 2-epimerase (hydrolyzing).
Alternative Name(s)
UDP-N-acetylglucosamine 2-epimerase.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + H(2)O <=> N-acetyl-D-mannosamine + UDP
  • The enzyme is found in mammalian liver, as well as in some pathogenic bacteria including Neisseria meningitidis and Staphylococcus aureus.
  • It catalyzes the first step of sialic acid (N-acetylneuraminic acid) biosynthesis.
  • The initial product formed is the alpha anomer, which rapidly mutarotates to a mixture of anomers.
  • The mammalian enzyme is bifunctional and also catalyzes EC
  • Cf. EC
PRIAM enzyme-specific profiles3.2.1.183
KEGG Ligand Database for Enzyme Nomenclature3.2.1.183
IUBMB Enzyme Nomenclature3.2.1.183
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