ENZYME entry: EC 3.2.1.184

Accepted Name
UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolyzing).
Alternative Name(s)
UDP-Bac2Ac(4)Ac 2-epimerase.
Reaction catalysed
UDP-N,N'-diacetylbacillosamine + H(2)O <=> UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose
Cofactor(s)
Magnesium.
Comment(s)
  • Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates.
  • The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D- mannopyranose, which rapidly mutarotates to a mixture of anomers.
  • The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine.
Cross-references
BRENDA3.2.1.184
EC2PDB3.2.1.184
ExplorEnz3.2.1.184
PRIAM enzyme-specific profiles3.2.1.184
KEGG Ligand Database for Enzyme Nomenclature3.2.1.184
IUBMB Enzyme Nomenclature3.2.1.184
IntEnz3.2.1.184
MEDLINEFind literature relating to 3.2.1.184
MetaCyc3.2.1.184
UniProtKB/Swiss-Prot
Q0P8T0, NEUCH_CAMJE;  Q5ZXH8, NEUCH_LEGPH;  

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