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ENZYME entry: EC 3.2.2.22

Accepted Name
rRNA N-glycosylase.
Alternative Name(s)
rRNA N-glycosidase.
Reaction catalysed
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA
Comment(s)
  • Ricin A-chain and related toxins show this activity.
  • Naked rRNA is attacked more slowly than rRNA in intact ribosomes.
  • Naked rRNA from Escherichia coli is cleaved at a corresponding position.
Cross-references
PROSITEPDOC00248
BRENDA3.2.2.22
EC2PDB3.2.2.22
ExplorEnz3.2.2.22
PRIAM enzyme-specific profiles3.2.2.22
KEGG Ligand Database for Enzyme Nomenclature3.2.2.22
IUBMB Enzyme Nomenclature3.2.2.22
IntEnz3.2.2.22
MEDLINEFind literature relating to 3.2.2.22
MetaCyc3.2.2.22
UniProtKB/Swiss-Prot
P11140, ABRA_ABRPR;  Q06077, ABRB_ABRPR;  P28590, ABRC_ABRPR;  
Q06076, ABRD_ABRPR;  Q9M6E9, AGGL_ABRPR;  P06750, AGGL_RICCO;  
P10593, ALB3_MAIZE;  P83572, ARALA_ARAEL;  P84072, CHAR_MOMCH;  
Q00531, JI60_HORVU;  P36230, LECA_IRIHO;  P81446, ML1_VISAL;  
Q6H266, ML2_VISAL;  P82683, ML3_VISAL;  Q6ITZ3, ML4_VISAL;  
P33183, NIGB_SAMNI;  Q1JPL7, PME18_ARATH;  P02879, RICI_RICCO;  
P24476, RIP0_DIACA;  P33185, RIP1_BRYDI;  Q9FRX4, RIP1_CUCFI;  
Q5F0I3, RIP1_GYNPE;  P22244, RIP1_HORVU;  P56568, RIP1_LUFAE;  
P16094, RIP1_MOMCH;  P10297, RIP1_PHYAM;  P93543, RIP1_SAMNI;  
P98185, RIP1_SAPOF;  P56626, RIP1_TRIAN;  P98184, RIP2_BRYDI;  
P24477, RIP2_DIACA;  P04399, RIP2_HORVU;  P29339, RIP2_MOMBA;  
Q40772, RIP2_PHYAM;  P34967, RIP2_PHYDI;  P27559, RIP2_SAPOF;  
P23029, RIP2_TRIKI;  P25891, RIP3_MAIZE;  P24817, RIP3_MOMCH;  
P27560, RIP3_SAPOF;  P24475, RIP3_SURMU;  Q6EH50, RIP4_PHYHE;  
P27561, RIP4_SAPOF;  Q41389, RIP5_SAPOF;  P20656, RIP6_SAPOF;  
Q41391, RIP7_SAPOF;  P25892, RIP9_MAIZE;  Q7M1Z2, RIP9_SAPOF;  
Q00465, RIPA_LUFAE;  Q03464, RIPA_PHYAM;  P22851, RIPB_LUFAE;  
P86144, RIPD1_PHYDI;  P85208, RIPD2_PHYDI;  P33186, RIPG_SURMU;  
P16093, RIPK_TRIKI;  P84853, RIPL1_PHYDI;  P84854, RIPL2_PHYDI;  
P85101, RIPLY_SILCH;  P84073, RIPL_LUFAE;  P21326, RIPP_MIRJA;  
P20655, RIPS_MOMCO;  P23339, RIPS_PHYAM;  P24478, RIPS_TRIKI;  
P09989, RIPT_TRIKI;  P80750, RIPX_CUCPE;  P28522, RIPX_MAIZE;  
P84531, RIP_CUCMO;  P84786, RIP_DRIMA;  P83324, RIP_FLAVE;  
P83245, RIP_LENTR;  P84530, RIP_LUFAC;  P83323, RIP_SIRGR;  
Q779K4, STXA_BP788;  P09385, STXA_BP933;  P08026, STXA_BPH19;  
P10149, STXA_BPH30;  Q32GM1, STXA_SHIDS;  Q9FBI2, STXA_SHIDY;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-