ENZYME entry: EC 3.2.2.23

Accepted Name
DNA-formamidopyrimidine glycosylase.
Alternative Name(s)
Fapy-DNA glycosylase.
Formamidopyrimidine-DNA glycosylase.
Reaction catalysed
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine
Comment(s)
  • May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents.
  • Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.
Cross-references
PROSITEPDOC00956
BRENDA3.2.2.23
EC2PDB3.2.2.23
ExplorEnz3.2.2.23
PRIAM enzyme-specific profiles3.2.2.23
KEGG Ligand Database for Enzyme Nomenclature3.2.2.23
IUBMB Enzyme Nomenclature3.2.2.23
IntEnz3.2.2.23
MEDLINEFind literature relating to 3.2.2.23
MetaCyc3.2.2.23
UniProtKB/Swiss-Prot
P9WNC2, FPG1_MYCTO;  P9WNC3, FPG1_MYCTU;  B0C5D4, FPG_ACAM1;  
Q6FE90, FPG_ACIAD;  B0VRV3, FPG_ACIBS;  A0LV85, FPG_ACIC1;  
A5FZ95, FPG_ACICJ;  B9ME52, FPG_ACIET;  B7J8I7, FPG_ACIF2;  
B5ENT6, FPG_ACIF5;  A1W4G6, FPG_ACISJ;  A3N3S8, FPG_ACTP2;  
B3GZD6, FPG_ACTP7;  B0BU16, FPG_ACTPJ;  A6VKA1, FPG_ACTSZ;  
A0KEN2, FPG_AERHH;  A4STD1, FPG_AERS4;  Q8UIH4, FPG_AGRT5;  
B9JZF5, FPG_AGRVS;  Q0VLB7, FPG_ALCBS;  Q0A598, FPG_ALKEH;  
B4S2C6, FPG_ALTMD;  Q3MDP1, FPG_ANAVT;  O80358, FPG_ARATH;  
Q5P728, FPG_AROAE;  A8IQM5, FPG_AZOC5;  Q81L04, FPG_BACAN;  
Q72ZF1, FPG_BACC1;  Q817G5, FPG_BACCR;  Q633L1, FPG_BACCZ;  
P19210, FPG_BACFI;  Q9K855, FPG_BACHD;  Q6HCU5, FPG_BACHK;  
Q65G93, FPG_BACLD;  Q5WEG7, FPG_BACSK;  O34403, FPG_BACSU;  
A1UU20, FPG_BARBK;  Q6G4T2, FPG_BARHE;  Q6G0L3, FPG_BARQU;  
A9IN26, FPG_BART1;  Q1LTS6, FPG_BAUCH;  Q6ML45, FPG_BDEBA;  
B2IE81, FPG_BEII9;  Q2KYB7, FPG_BORA1;  Q7W185, FPG_BORPA;  
A9I6Y3, FPG_BORPD;  Q7VUG7, FPG_BORPE;  Q89WC9, FPG_BRADU;  
A5E887, FPG_BRASB;  A4YJG9, FPG_BRASO;  C0Z7Z0, FPG_BREBN;  
B2S9T2, FPG_BRUA1;  Q2YQP8, FPG_BRUA2;  Q57A83, FPG_BRUAB;  
A9MAB2, FPG_BRUC2;  C0RG65, FPG_BRUMB;  Q8YED2, FPG_BRUME;  
A5VTD0, FPG_BRUO2;  Q8FXR6, FPG_BRUSU;  B1YN48, FPG_BURA4;  
Q1BTH0, FPG_BURCA;  A0KAM1, FPG_BURCH;  B4EAR7, FPG_BURCJ;  
A9AEZ2, FPG_BURM1;  A2S6C0, FPG_BURM9;  Q62FC7, FPG_BURMA;  
A1UZN2, FPG_BURMS;  A3NRA1, FPG_BURP0;  Q3JW82, FPG_BURP1;  
A3N5K5, FPG_BURP6;  B2JCP3, FPG_BURP8;  B2SXG9, FPG_BURPP;  
Q63XL4, FPG_BURPS;  Q39CU4, FPG_BURS3;  Q2T1B3, FPG_BURTA;  
A4JHZ1, FPG_BURVG;  Q145W8, FPG_BURXL;  Q3ABL4, FPG_CARHZ;  
B8GVY4, FPG_CAUCN;  Q9A259, FPG_CAUCR;  B0T7D1, FPG_CAUSK;  
B3PG51, FPG_CELJU;  Q11AV8, FPG_CHESB;  A9WDC2, FPG_CHLAA;  
B8G9X1, FPG_CHLAD;  Q7NQS5, FPG_CHRVO;  A8ARM2, FPG_CITK8;  
Q48AD4, FPG_COLP3;  C3PH91, FPG_CORA7;  Q6NGH4, FPG_CORDI;  
Q8FP17, FPG_COREF;  A4QFD9, FPG_CORGB;  Q8NNV7, FPG_CORGL;  
Q4JUY8, FPG_CORJK;  B1VG60, FPG_CORU7;  A7MQ97, FPG_CROS8;  
Q0KEP4, FPG_CUPNH;  Q476F5, FPG_CUPPJ;  B2AGU2, FPG_CUPTR;  
B1WTF7, FPG_CYAA5;  B7K1T1, FPG_CYAP8;  Q479M6, FPG_DECAR;  
Q9RX22, FPG_DEIRA;  C6BUX8, FPG_DESAD;  B8FU83, FPG_DESHD;  
Q24XW2, FPG_DESHY;  Q6APT2, FPG_DESPS;  A4J4X3, FPG_DESRM;  
Q726D5, FPG_DESVH;  A5EXK6, FPG_DICNV;  A8LNK8, FPG_DINSH;  
A7ZTI6, FPG_ECO24;  B7ULJ0, FPG_ECO27;  B7MFJ6, FPG_ECO45;  
B7L758, FPG_ECO55;  P64148, FPG_ECO57;  B5YWD3, FPG_ECO5E;  
B7NPE1, FPG_ECO7I;  B7N2X1, FPG_ECO81;  B7M4B9, FPG_ECO8A;  
C4ZXM7, FPG_ECOBW;  B1X969, FPG_ECODH;  A8A697, FPG_ECOHS;  
A1AHG8, FPG_ECOK1;  Q0TBH4, FPG_ECOL5;  Q8FC87, FPG_ECOL6;  
B1IZF8, FPG_ECOLC;  P05523, FPG_ECOLI;  B7NET9, FPG_ECOLU;  
B6I3L2, FPG_ECOSE;  B1LK72, FPG_ECOSM;  Q1R4V8, FPG_ECOUT;  
C5B9D8, FPG_EDWI9;  A4W514, FPG_ENT38;  Q837G3, FPG_ENTFA;  
B2VF70, FPG_ERWT9;  Q2N7Y8, FPG_ERYLH;  B7LVJ6, FPG_ESCF3;  
B1YKA0, FPG_EXIS2;  C4L470, FPG_EXISA;  A8L594, FPG_FRASN;  
Q5NGY3, FPG_FRATT;  B9M5V2, FPG_GEODF;  Q5KWC3, FPG_GEOKA;  
Q39WD1, FPG_GEOMG;  Q74EG5, FPG_GEOSL;  A5G7Q9, FPG_GEOUR;  
Q7NFW7, FPG_GLOVI;  A9HI30, FPG_GLUDA;  Q5FN17, FPG_GLUOX;  
Q7VN67, FPG_HAEDU;  Q4QLW2, FPG_HAEI8;  A5UDC3, FPG_HAEIE;  
A5UI87, FPG_HAEIG;  P44948, FPG_HAEIN;  B8F586, FPG_HAEPS;  
Q2SPF3, FPG_HAHCH;  A1WZG2, FPG_HALHL;  B0TER7, FPG_HELMI;  
A9B0X2, FPG_HERA2;  A4G916, FPG_HERAR;  Q0I0X6, FPG_HISS1;  
B0UUX0, FPG_HISS2;  Q5QZC1, FPG_IDILO;  A6T2R7, FPG_JANMA;  
Q28JI5, FPG_JANSC;  A6W7S6, FPG_KINRD;  B5XTG8, FPG_KLEP3;  
A6TFM6, FPG_KLEP7;  Q5FIV8, FPG_LACAC;  Q1G9A3, FPG_LACDA;  
Q049F3, FPG_LACDB;  Q041U1, FPG_LACGA;  A8YWE6, FPG_LACH4;  
Q74IB5, FPG_LACJO;  Q9CIK4, FPG_LACLA;  P42371, FPG_LACLC;  
Q88WV4, FPG_LACPL;  Q1WUN7, FPG_LACS1;  Q38VS5, FPG_LACSS;  
C1DBB4, FPG_LARHH;  Q5X7I9, FPG_LEGPA;  Q5ZY18, FPG_LEGPH;  
Q5WYY6, FPG_LEGPL;  Q6AFJ3, FPG_LEIXX;  B1Y3P5, FPG_LEPCP;  
Q92BF1, FPG_LISIN;  Q71ZA3, FPG_LISMF;  Q8Y6W7, FPG_LISMO;  
A0L837, FPG_MAGSM;  Q65R59, FPG_MANSM;  A1U749, FPG_MARHV;  
A6VSY6, FPG_MARMS;  B7KN75, FPG_METC4;  Q602J1, FPG_METCA;  
A9W8R7, FPG_METEP;  Q1H3I3, FPG_METFK;  B8IIZ9, FPG_METNO;  
B1ZGU8, FPG_METPB;  B1LWY6, FPG_METRJ;  B0UR68, FPG_METS4;  
B8EKR5, FPG_METSB;  Q5UQ00, FPG_MIMIV;  Q2RHE9, FPG_MOOTA;  
A0QJ66, FPG_MYCA1;  B1MDL2, FPG_MYCA9;  P64151, FPG_MYCBO;  
A1KMR9, FPG_MYCBP;  C1AG40, FPG_MYCBT;  P55825, FPG_MYCGE;  
A4TE57, FPG_MYCGI;  B8ZRZ2, FPG_MYCLB;  O69470, FPG_MYCLE;  
B2HJJ6, FPG_MYCMM;  Q6KHS0, FPG_MYCMO;  Q73VL9, FPG_MYCPA;  
P75402, FPG_MYCPN;  Q98QQ1, FPG_MYCPU;  A0QV21, FPG_MYCS2;  
A3PXU1, FPG_MYCSJ;  A1UED7, FPG_MYCSK;  Q1BAM5, FPG_MYCSS;  
A5U6T0, FPG_MYCTA;  A0PQ49, FPG_MYCUA;  A1T737, FPG_MYCVP;  
Q5F8Z9, FPG_NEIG1;  P57014, FPG_NEIMA;  P55044, FPG_NEIMB;  
Q0AD66, FPG_NITEC;  Q82S12, FPG_NITEU;  Q2YBI1, FPG_NITMU;  
Q3J7U5, FPG_NITOC;  Q3SWN3, FPG_NITWN;  Q5YS09, FPG_NOCFA;  
A1SLU7, FPG_NOCSJ;  B2J5G0, FPG_NOSP7;  Q8YP80, FPG_NOSS1;  
Q2GAT0, FPG_NOVAD;  Q8EPE6, FPG_OCEIH;  B6JCQ7, FPG_OLICO;  
A1BAN2, FPG_PARDP;  A7HZC4, FPG_PARL1;  Q6MCT3, FPG_PARUW;  
P57910, FPG_PASMU;  Q6DAV4, FPG_PECAS;  C6DIB8, FPG_PECCP;  
Q03GC2, FPG_PEDPA;  Q3A3F2, FPG_PELCD;  A1AV29, FPG_PELPD;  
A5D0T6, FPG_PELTS;  B4RC43, FPG_PHEZH;  Q8VW76, FPG_PHODP;  
Q7MY36, FPG_PHOLL;  Q6LVN0, FPG_PHOPR;  A1VKP2, FPG_POLNA;  
B1XS61, FPG_POLNS;  Q12DZ5, FPG_POLSJ;  A3PB53, FPG_PROM0;  
A2C0H4, FPG_PROM1;  A8G2Y9, FPG_PROM2;  A9BDY5, FPG_PROM4;  
A2BUV8, FPG_PROM5;  Q31CK0, FPG_PROM9;  Q7VDK6, FPG_PROMA;  
B4F0X6, FPG_PROMH;  Q7V8Y5, FPG_PROMM;  Q7V2X4, FPG_PROMP;  
A2BPD1, FPG_PROMS;  Q46H41, FPG_PROMT;  Q48CK1, FPG_PSE14;  
Q15ZV5, FPG_PSEA6;  A6UYG0, FPG_PSEA7;  B7V2S0, FPG_PSEA8;  
Q02U58, FPG_PSEAB;  Q9L7T2, FPG_PSEAE;  Q1IGF3, FPG_PSEE4;  
Q4K4A5, FPG_PSEF5;  C3K3N6, FPG_PSEFS;  A4Y028, FPG_PSEMY;  
A5WAF9, FPG_PSEP1;  Q3K566, FPG_PSEPF;  B0KN79, FPG_PSEPG;  
Q88CQ5, FPG_PSEPK;  B1J2M4, FPG_PSEPW;  Q88AH6, FPG_PSESM;  
Q4ZM34, FPG_PSEU2;  A4VRM9, FPG_PSEU5;  Q4FUU7, FPG_PSYA2;  
A1SR12, FPG_PSYIN;  Q1LRP7, FPG_RALME;  B2UES0, FPG_RALPJ;  
Q8Y2D7, FPG_RALSO;  B3PZ93, FPG_RHIE6;  Q2KDA9, FPG_RHIEC;  
Q1MMD9, FPG_RHIL3;  Q98BG6, FPG_RHILO;  B5ZYK9, FPG_RHILW;  
Q59752, FPG_RHIME;  C3MCY7, FPG_RHISN;  B6IVU4, FPG_RHOCS;  
C0ZXQ5, FPG_RHOE4;  Q21XW7, FPG_RHOFT;  C1B2Q5, FPG_RHOOB;  
Q2J2I0, FPG_RHOP2;  Q07UF4, FPG_RHOP5;  Q6NDM1, FPG_RHOPA;  
Q21CD4, FPG_RHOPB;  Q13EN7, FPG_RHOPS;  B3Q620, FPG_RHOPT;  
Q2RMQ2, FPG_RHORT;  A3PFL2, FPG_RHOS1;  Q3IY64, FPG_RHOS4;  
A4WVR6, FPG_RHOS5;  B9KQJ9, FPG_RHOSK;  Q0S2E0, FPG_RHOSR;  
C3PLF5, FPG_RICAE;  A8GXR0, FPG_RICB8;  Q1RJY6, FPG_RICBR;  
A8EZP5, FPG_RICCK;  Q92GT4, FPG_RICCN;  Q4UMW5, FPG_RICFE;  
A8F2H0, FPG_RICM5;  C4K2K4, FPG_RICPU;  B0BUU0, FPG_RICRO;  
A8GTA0, FPG_RICRS;  A7NQM8, FPG_ROSCS;  Q16DL0, FPG_ROSDO;  
A5UUN1, FPG_ROSS1;  Q5LWT9, FPG_RUEPO;  Q1GC55, FPG_RUEST;  
A1AW02, FPG_RUTMC;  Q21EE3, FPG_SACD2;  A4FMJ7, FPG_SACEN;  
B5EXE0, FPG_SALA4;  A8M661, FPG_SALAI;  A9MKN9, FPG_SALAR;  
Q57IA7, FPG_SALCH;  B5FM59, FPG_SALDC;  B5R5F9, FPG_SALEP;  
B5RGF2, FPG_SALG2;  B4T9C0, FPG_SALHS;  B4SXD7, FPG_SALNS;  
Q5PC09, FPG_SALPA;  A9MVN0, FPG_SALPB;  C0Q1W8, FPG_SALPC;  
B5BI09, FPG_SALPK;  B4TZX7, FPG_SALSV;  Q8Z2H2, FPG_SALTI;  
A4X4F8, FPG_SALTO;  O54326, FPG_SALTY;  Q9X981, FPG_SERMA;  
A8GLE2, FPG_SERP5;  A1S1S3, FPG_SHEAM;  B8EDQ9, FPG_SHEB2;  
A3CYP7, FPG_SHEB5;  A6WUE9, FPG_SHEB8;  A9KW47, FPG_SHEB9;  
Q12SR9, FPG_SHEDO;  B0TN04, FPG_SHEHH;  A3QJA8, FPG_SHELP;  
Q8E8D9, FPG_SHEON;  A8HA27, FPG_SHEPA;  B8CVD1, FPG_SHEPW;  
A0L2N2, FPG_SHESA;  Q0HDC3, FPG_SHESM;  Q0HPK4, FPG_SHESR;  
A1RE25, FPG_SHESW;  B1KL38, FPG_SHEWM;  B2TTU9, FPG_SHIB3;  
Q31UZ1, FPG_SHIBS;  Q329M2, FPG_SHIDS;  Q0SYG3, FPG_SHIF8;  
P64149, FPG_SHIFL;  Q3YVZ7, FPG_SHISS;  A6UFF8, FPG_SINMW;  
Q2NQU4, FPG_SODGM;  Q01RU9, FPG_SOLUE;  Q1GN82, FPG_SPHAL;  
A5VG06, FPG_SPHWW;  Q3K028, FPG_STRA1;  P64152, FPG_STRA3;  
P64153, FPG_STRA5;  Q82JU0, FPG_STRAW;  Q9ZBQ6, FPG_STRCO;  
B1VYY1, FPG_STRGG;  B4SRN0, FPG_STRM5;  B2FU49, FPG_STRMK;  
P55045, FPG_STRMU;  Q9A131, FPG_STRP1;  P0DB14, FPG_STRP3;  
Q5XDE4, FPG_STRP6;  Q8P250, FPG_STRP8;  Q48UU6, FPG_STRPM;  
Q97R61, FPG_STRPN;  P0DB15, FPG_STRPQ;  Q8DQ33, FPG_STRR6;  
Q5M0P0, FPG_STRT1;  Q5M576, FPG_STRT2;  Q67R59, FPG_SYMTH;  
P95744, FPG_SYNEL;  Q08079, FPG_SYNP6;  Q7U4V2, FPG_SYNPX;  
Q0AVE3, FPG_SYNWW;  P74290, FPG_SYNY3;  C5BLG1, FPG_TERTT;  
P59065, FPG_THEEB;  Q47S77, FPG_THEFY;  B9L1Z5, FPG_THERP;  
Q72HN2, FPG_THET2;  O50606, FPG_THET8;  Q31EB2, FPG_THICR;  
Q3SLR9, FPG_THIDA;  B8GUQ6, FPG_THISH;  Q117D2, FPG_TRIEI;  
Q9PQ76, FPG_UREPA;  C5CYZ1, FPG_VARPS;  A5CX90, FPG_VESOH;  
A5F407, FPG_VIBC3;  A7MSN3, FPG_VIBCB;  Q9KVC5, FPG_VIBCH;  
C3LQI3, FPG_VIBCM;  Q5E8M1, FPG_VIBF1;  B5FFG1, FPG_VIBFM;  
Q87T81, FPG_VIBPA;  B7VHK6, FPG_VIBSL;  Q8DDY4, FPG_VIBVU;  
Q7MPS3, FPG_VIBVY;  Q73G10, FPG_WOLPM;  B3CM71, FPG_WOLPP;  
Q5GS47, FPG_WOLTR;  C0R4I6, FPG_WOLWR;  Q8PEQ4, FPG_XANAC;  
Q3BM92, FPG_XANC5;  Q4UNU6, FPG_XANC8;  B0RZ50, FPG_XANCB;  
Q8P3C4, FPG_XANCP;  Q2P8V2, FPG_XANOM;  B2STU3, FPG_XANOP;  
Q5H667, FPG_XANOR;  A7IKJ3, FPG_XANP2;  P64154, FPG_XYLFA;  
P64155, FPG_XYLFT;  A1JHR7, FPG_YERE8;  A7FCT7, FPG_YERP3;  
Q1C270, FPG_YERPA;  B2JYN6, FPG_YERPB;  Q8ZJP0, FPG_YERPE;  
A9R677, FPG_YERPG;  Q1CD05, FPG_YERPN;  A4TSD4, FPG_YERPP;  
Q66GD3, FPG_YERPS;  B1JQX0, FPG_YERPY;  Q9X3X1, FPG_ZYMMO;  

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