ENZYME entry: EC 3.2.2.29
| Accepted Name |
|---|
| Thymine-DNA glycosylase.
|
| Alternative Name(s) |
|---|
| Mismatch-specific thymine-DNA glycosylase. |
| Mismatch-specific thymine-DNA N-glycosylase. |
| TDG. |
| Thymine DNA glycosylase. |
| Uracil/thymine DNA glycosylase. |
| Reaction catalysed |
|---|
| Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine |
| Comment(s) |
|---|
- Thymine-DNA glycosylase is part of the DNA-repair machinery.
- Thymine removal is fastest when it is from a G/T mismatch with a
5'-flanking C/G pair.
- The glycosylase removes uracil from G/U, C/U, and T/U base pairs
faster than it removes thymine from G/T.
|
| Cross-references |
|---|
| BRENDA | 3.2.2.29 |
| EC2PDB | 3.2.2.29 |
| ExplorEnz | 3.2.2.29 |
| PRIAM enzyme-specific profiles | 3.2.2.29 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.2.2.29 |
| IUBMB Enzyme Nomenclature | 3.2.2.29 |
| IntEnz | 3.2.2.29 |
| MEDLINE | Find literature relating to 3.2.2.29 |
| MetaCyc | 3.2.2.29 |
| UniProtKB/Swiss-Prot |
|
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