ENZYME entry: EC 3.3.2.6

Accepted Name
Leukotriene-A(4) hydrolase.
Alternative Name(s)
Leukotriene A(4) hydrolase.
Leukotriene-A4 hydrolase.
LTA-4 hydrolase.
Reaction catalysed
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
Cofactor(s)
Zinc.
Comment(s)
  • A bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities.
  • It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates.
  • It also converts leukotriene A(4) into leukotriene B(4), unlike EC 3.2.2.10 which converts leukotriene A(4) into 5,6-dihydroxy- 7,9,11,14-eicosatetraenoic acid.
Cross-references
PROSITEPDOC00129
BRENDA3.3.2.6
EC2PDB3.3.2.6
ExplorEnz3.3.2.6
PRIAM enzyme-specific profiles3.3.2.6
KEGG Ligand Database for Enzyme Nomenclature3.3.2.6
IUBMB Enzyme Nomenclature3.3.2.6
IntEnz3.3.2.6
MEDLINEFind literature relating to 3.3.2.6
MetaCyc3.3.2.6
UniProtKB/Swiss-Prot
A5DME6, LKA41_PICGU;  A3LRX6, LKA41_PICST;  A5DGF3, LKA42_PICGU;  
A3LQI7, LKA42_PICST;  A6RCT2, LKHA4_AJECN;  Q9FY49, LKHA4_ARATH;  
Q75B10, LKHA4_ASHGO;  A1CSI2, LKHA4_ASPCL;  Q4X265, LKHA4_ASPFU;  
A2QKF8, LKHA4_ASPNC;  Q2TZ99, LKHA4_ASPOR;  Q0CFY9, LKHA4_ASPTN;  
A6SAG8, LKHA4_BOTFB;  Q3SZH7, LKHA4_BOVIN;  Q59NB8, LKHA4_CANAL;  
Q6FTM0, LKHA4_CANGA;  P19602, LKHA4_CAVPO;  Q2GY21, LKHA4_CHAGB;  
Q6S9C8, LKHA4_CHILA;  Q1DVD1, LKHA4_COCIM;  Q6BW21, LKHA4_DEBHA;  
P52922, LKHA4_DICDI;  Q5B0W8, LKHA4_EMENI;  P09960, LKHA4_HUMAN;  
Q6CLD3, LKHA4_KLULA;  A5DSS4, LKHA4_LODEL;  A4QUC1, LKHA4_MAGO7;  
P24527, LKHA4_MOUSE;  A1DG68, LKHA4_NEOFI;  Q7S785, LKHA4_NEUCR;  
Q84TA3, LKHA4_ORYSJ;  Q0U653, LKHA4_PHANO;  P30349, LKHA4_RAT;  
O94544, LKHA4_SCHPO;  A7EJL9, LKHA4_SCLS1;  A7THG7, LKHA4_VANPO;  
Q6C3E5, LKHA4_YARLI;  A6ZS33, LKHA4_YEAS7;  Q10740, LKHA4_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-