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ENZYME

ENZYME entry: EC 3.3.2.6

Accepted Name
leukotriene-A4 hydrolase
Alternative Name(s)
leukotriene A4 hydrolase
LTA-4 hydrolase
Reaction catalysed
H2O + leukotriene A4 <=> leukotriene B4
Comment(s)
  • A bifunctional zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities.
  • It preferentially cleaves tripeptides at an arginyl bond, with dipeptides and tetrapeptides being poorer substrates.
  • It also converts leukotriene A4 into leukotriene B4, unlike EC 3.2.2.10 which converts leukotriene A4 into 5,6-dihydroxy- 7,9,11,14-eicosatetraenoic acid.
Cross-references
BRENDA3.3.2.6
EC2PDB3.3.2.6
ExplorEnz3.3.2.6
PRIAM enzyme-specific profiles3.3.2.6
KEGG Ligand Database for Enzyme Nomenclature3.3.2.6
IUBMB Enzyme Nomenclature3.3.2.6
IntEnz3.3.2.6
MEDLINEFind literature relating to 3.3.2.6
MetaCyc3.3.2.6
Rhea expert-curated reactions3.3.2.6
UniProtKB/Swiss-Prot
A6SAG8, LKHA4_BOTFBQ3SZH7, LKHA4_BOVINP19602, LKHA4_CAVPO
Q6S9C8, LKHA4_CHILAP09960, LKHA4_HUMANP24527, LKHA4_MOUSE
P30349, LKHA4_RATQ6IP81, LKHA4_XENLA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-