ENZYME entry: EC 3.4.15.1
| Accepted Name |
|---|
| Peptidyl-dipeptidase A.
|
| Alternative Name(s) |
|---|
| ACE. |
| Angiotensin I-converting enzyme. |
| Carboxycathepsin. |
| Dipeptidyl carboxypeptidase I. |
| Kininase II. |
| Peptidase P. |
| Peptidyl dipeptidase I. |
| Reaction catalysed |
|---|
| Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II |
| Cofactor(s) |
|---|
| Zinc.
|
| Comment(s) |
|---|
- Cl(-)-dependent.
- A glycoprotein that is generally membrane-bound.
- Active at neutral pH.
- Only single dipeptides are released from angiotensin I and bradykinin
because of the lack of activity on bonds involving proline.
- Belongs to peptidase family M2.
|
| Cross-references |
|---|
| PROSITE | PDOC00129 |
| BRENDA | 3.4.15.1 |
| EC2PDB | 3.4.15.1 |
| ExplorEnz | 3.4.15.1 |
| PRIAM enzyme-specific profiles | 3.4.15.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.15.1 |
| IUBMB Enzyme Nomenclature | 3.4.15.1 |
| IntEnz | 3.4.15.1 |
| MEDLINE | Find literature relating to 3.4.15.1 |
| MetaCyc | 3.4.15.1 |
| UniProtKB/Swiss-Prot |
| Q9VLJ6, ACER_DROME; | P12820, ACE_BOVIN; | Q10751, ACE_CHICK; |
| Q10714, ACE_DROME; | Q10715, ACE_HAEIX; | P12821, ACE_HUMAN; |
| Q50JE5, ACE_MESAU; | P09470, ACE_MOUSE; | Q9GLN7, ACE_PANTR; |
| P12822, ACE_RABIT; | P47820, ACE_RAT; | Q6Q4G4, ACE_THETS; |
|
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