ENZYME entry: EC 3.4.19.15

Accepted Name
Desampylase.
Alternative Name(s)
SAMP-protein conjugate cleaving protease.
Reaction catalysed
An N(6)-[small archaeal modifier protein]-[protein]-L-lysine + H(2)O <=> a [protein]-L-lysine + a [small archaeal modifier protein]
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolyzing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein.
  • Cf. EC 3.4.19.12.
  • Belongs to peptidase family M67.
  • Formerly EC 3.4.24.88.
Cross-references
BRENDA3.4.19.15
EC2PDB3.4.19.15
ExplorEnz3.4.19.15
PRIAM enzyme-specific profiles3.4.19.15
KEGG Ligand Database for Enzyme Nomenclature3.4.19.15
IUBMB Enzyme Nomenclature3.4.19.15
IntEnz3.4.19.15
MEDLINEFind literature relating to 3.4.19.15
MetaCyc3.4.19.15
UniProtKB/Swiss-Prot
D4GTS4, JAMM1_HALVD

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