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ENZYME

ENZYME entry: EC 3.4.19.15

Accepted Name
desampylase
Alternative Name(s)
SAMP-protein conjugate cleaving protease
Reaction catalysed
an N(6)-[small archaeal modifier protein]-[protein]-L-lysine + H2O <=> a [protein]-L-lysine + a [small archaeal modifier protein]
Comment(s)
  • The enzyme, characterized from the archaeon Haloferax volcanii, specifically cleaves the ubiquitin-like small modifier proteins SAMP1 and SAMP2 from protein conjugates, hydrolyzing the isopeptide bond between a lysine residue of the target protein and the C-terminal glycine of the modifier protein. cf. EC 3.4.19.12.
  • Belongs to peptidase family M67.
  • Formerly EC 3.4.24.88.
Cross-references
BRENDA3.4.19.15
EC2PDB3.4.19.15
ExplorEnz3.4.19.15
PRIAM enzyme-specific profiles3.4.19.15
KEGG Ligand Database for Enzyme Nomenclature3.4.19.15
IUBMB Enzyme Nomenclature3.4.19.15
IntEnz3.4.19.15
MEDLINEFind literature relating to 3.4.19.15
MetaCyc3.4.19.15
Rhea expert-curated reactions3.4.19.15
UniProtKB/Swiss-Prot
D4GTS4, JAMM1_HALVDQ8U1Y4, JAMM1_PYRFU

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