ENZYME entry: EC 3.4.19.6

Accepted Name
Pyroglutamyl-peptidase II.
Alternative Name(s)
PAP-II.
Pyroglutamyl aminopeptidase II.
Thyroliberinase.
Thyrotropin-releasing hormone degrading ectoenzyme.
TRH-DE.
TRH-degrading ectoenzyme.
TRH-specific aminopeptidase.
Reaction catalysed
Release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa tripeptides and pGlu-|-His-Xaa-Gly tetrapeptides
Cofactor(s)
Zn(2+).
Comment(s)
  • Highly specific for thyrotropin releasing hormone (pyroglutamyl- histidyl-prolylamide).
  • Will not cleave the pyroglutamyl-histidyl bond of luteinizing hormone releasing hormone.
  • Found in serum and brain.
  • Inhibited by metal chelators.
  • Belongs to peptidase family M1.
Cross-references
PROSITEPDOC00129
BRENDA3.4.19.6
EC2PDB3.4.19.6
ExplorEnz3.4.19.6
PRIAM enzyme-specific profiles3.4.19.6
KEGG Ligand Database for Enzyme Nomenclature3.4.19.6
IUBMB Enzyme Nomenclature3.4.19.6
IntEnz3.4.19.6
MEDLINEFind literature relating to 3.4.19.6
MetaCyc3.4.19.6
UniProtKB/Swiss-Prot
Q9UKU6, TRHDE_HUMAN;  Q8K093, TRHDE_MOUSE;  Q10836, TRHDE_RAT;  

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