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ENZYME entry: EC

Accepted Name
Mannan-binding lectin-associated serine protease-2.
Alternative Name(s)
Mannan-binding lectin-associated serine peptidase 2.
Mannose-binding lectin-associated serine protease-2.
MBP-associated serine protease-2.
Reaction catalysed
Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile)
  • Mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine, on a wide range of microbial surfaces and is able to initiate activation of the lectin pathway of complement.
  • Displays C1s-like esterolytic activity (cf. EC
  • It also cleaves C4 and C2 with efficiencies that are relatively higher than those of EC
  • Belongs to peptidase family S1A.
PRIAM enzyme-specific profiles3.4.21.104
KEGG Ligand Database for Enzyme Nomenclature3.4.21.104
IUBMB Enzyme Nomenclature3.4.21.104
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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