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ENZYME entry: EC 126.96.36.199
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|Mannan-binding lectin-associated serine protease-2.
|Mannan-binding lectin-associated serine peptidase 2.|
|Mannose-binding lectin-associated serine protease-2.|
|MBP-associated serine protease-2.|
|Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile)|
- Mannan-binding lectin (MBL) recognizes patterns of neutral
carbohydrates, such as mannose and N-acetylglucosamine, on a wide
range of microbial surfaces and is able to initiate activation of the
lectin pathway of complement.
- Displays C1s-like esterolytic activity (cf. EC 188.8.131.52).
- It also cleaves C4 and C2 with efficiencies that are relatively
higher than those of EC 184.108.40.206.
- Belongs to peptidase family S1A.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
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