ENZYME entry: EC 3.4.21.105

Accepted Name
Rhomboid protease.
Reaction catalysed
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains
Comment(s)
  • These endopeptidases are multi-spanning membrane proteins.
  • Their catalytic site is embedded within the membrane and they cleave type-1 transmembrane domains.
  • Important for embryo development in Drosophila melanogaster.
  • Rhomboid is a key regulator of EGF receptor signaling and is responsible for cleaving Spitz, the main ligand of the Drosophila EGF receptor pathway.
  • Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.
  • Belongs to peptidase family S54.
Cross-references
BRENDA3.4.21.105
EC2PDB3.4.21.105
ExplorEnz3.4.21.105
PRIAM enzyme-specific profiles3.4.21.105
KEGG Ligand Database for Enzyme Nomenclature3.4.21.105
IUBMB Enzyme Nomenclature3.4.21.105
IntEnz3.4.21.105
MEDLINEFind literature relating to 3.4.21.105
MetaCyc3.4.21.105
UniProtKB/Swiss-Prot
P46116, AARA_PROST;  A8AQX4, GLPG_CITK8;  A7ZSV4, GLPG_ECO24;  
B7UKC8, GLPG_ECO27;  B7MDQ0, GLPG_ECO45;  B7L4V0, GLPG_ECO55;  
Q8X6Z6, GLPG_ECO57;  B5YTX6, GLPG_ECO5E;  B7NMI8, GLPG_ECO7I;  
B7N156, GLPG_ECO81;  B7M2I4, GLPG_ECO8A;  C4ZVX5, GLPG_ECOBW;  
B1X769, GLPG_ECODH;  A8A5N2, GLPG_ECOHS;  A1AGU7, GLPG_ECOK1;  
Q0TC44, GLPG_ECOL5;  Q8FCS5, GLPG_ECOL6;  B1IP42, GLPG_ECOLC;  
P09391, GLPG_ECOLI;  B7NE28, GLPG_ECOLU;  B6I2Y7, GLPG_ECOSE;  
B1LI84, GLPG_ECOSM;  Q1R5L1, GLPG_ECOUT;  A4WFK8, GLPG_ENT38;  
B7LSC6, GLPG_ESCF3;  P44783, GLPG_HAEIN;  B5XTR5, GLPG_KLEP3;  
A6TF43, GLPG_KLEP7;  Q6CZL3, GLPG_PECAS;  Q7N9W4, GLPG_PHOLL;  
B5F8P0, GLPG_SALA4;  A9MMA7, GLPG_SALAR;  Q57IV1, GLPG_SALCH;  
B5FKE3, GLPG_SALDC;  B5R383, GLPG_SALEP;  B5R7J1, GLPG_SALG2;  
B4TKV0, GLPG_SALHS;  B4SVM1, GLPG_SALNS;  Q5PLZ8, GLPG_SALPA;  
B5BHH5, GLPG_SALPK;  B4TY77, GLPG_SALSV;  Q8Z229, GLPG_SALTI;  
Q8ZLH5, GLPG_SALTY;  A8GKU2, GLPG_SERP5;  B2U3N2, GLPG_SHIB3;  
Q31VK9, GLPG_SHIBS;  Q32AN6, GLPG_SHIDS;  Q0SZP2, GLPG_SHIF8;  
Q83PV6, GLPG_SHIFL;  Q3YWA4, GLPG_SHISS;  Q2NQH3, GLPG_SODGM;  
A1JSF0, GLPG_YERE8;  A7FNW6, GLPG_YERP3;  Q1C2L2, GLPG_YERPA;  
B2K5W4, GLPG_YERPB;  Q7CFX8, GLPG_YERPE;  Q1CCK6, GLPG_YERPN;  
A4TGR2, GLPG_YERPP;  Q664J1, GLPG_YERPS;  B1JHY8, GLPG_YERPY;  
P54493, GLUP_BACSU;  Q2KHV4, PARL_BOVIN;  Q58EK4, PARL_DANRE;  
Q9H300, PARL_HUMAN;  Q5XJY4, PARL_MOUSE;  Q5R5H4, PARL_PONAB;  
Q3B8P0, PARL_RAT;  P53259, PCP1_YEAST;  O75783, RHBL1_HUMAN;  
Q8VC82, RHBL1_MOUSE;  O88779, RHBL1_RAT;  Q695U0, RHBL1_TOXGO;  
Q9NX52, RHBL2_HUMAN;  A2AGA4, RHBL2_MOUSE;  Q695T9, RHBL2_TOXGO;  
P58872, RHBL3_HUMAN;  P58873, RHBL3_MOUSE;  Q6IUY1, RHBL3_TOXGO;  
Q8TEB9, RHBL4_HUMAN;  Q8BHC7, RHBL4_MOUSE;  Q5RBS4, RHBL4_PONAB;  
Q4V8F3, RHBL4_RAT;  Q695T8, RHBL4_TOXGO;  Q6GV23, RHBL5_TOXGO;  
Q2PP52, RHBL6_TOXGO;  P20350, RHOM_DROME;  Q19821, ROM1_CAEEL;  
P34356, ROM2_CAEEL;  

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