ENZYME entry: EC 3.4.21.108

Accepted Name
HtrA2 peptidase.
Alternative Name(s)
High temperature requirement protein A2.
HtrA2 protease.
Omi stress-regulated endoprotease.
Serine proteinase OMI.
Reaction catalysed
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues
Comment(s)
  • Up-regulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment.
  • Can induce apoptosis in a caspase-independent manner through its peptidase activity and in a caspase-dependent manner by disrupting the interaction between caspase and the inhibitor of apoptosis (IAP).
  • Belongs to peptidase family S1B.
Cross-references
BRENDA3.4.21.108
EC2PDB3.4.21.108
ExplorEnz3.4.21.108
PRIAM enzyme-specific profiles3.4.21.108
KEGG Ligand Database for Enzyme Nomenclature3.4.21.108
IUBMB Enzyme Nomenclature3.4.21.108
IntEnz3.4.21.108
MEDLINEFind literature relating to 3.4.21.108
MetaCyc3.4.21.108
UniProtKB/Swiss-Prot
A0JNK3, HTRA2_BOVIN;  B3LVG7, HTRA2_DROAN;  B3P3J9, HTRA2_DROER;  
B4JTT7, HTRA2_DROGR;  Q9VFJ3, HTRA2_DROME;  B4K835, HTRA2_DROMO;  
B4G316, HTRA2_DROPE;  Q297U2, HTRA2_DROPS;  B4HEM8, HTRA2_DROSE;  
B4QZU6, HTRA2_DROSI;  B4LY58, HTRA2_DROVI;  B4N937, HTRA2_DROWI;  
B4PST0, HTRA2_DROYA;  O43464, HTRA2_HUMAN;  Q9JIY5, HTRA2_MOUSE;  

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