ENZYME entry: EC 3.4.21.110
| Accepted Name |
|---|
| C5a peptidase.
|
| Alternative Name(s) |
|---|
| SCP. |
| Streptococcal C5a peptidase. |
| Reaction catalysed |
|---|
| The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59 |
| Comment(s) |
|---|
- Surface-associated subtilisin-like serine peptidase with very
specific substrate specificity.
- Virulent strains of streptococci, including Streptococcus pyogenes,
can evade human detection and phagocytosis by destroying the
complement chemotaxin C5a.
- Cleavage of human C5a by this enzyme reduces the ability of C5a to
bind receptors on the surface of polymorphonuclear neutrophil
leukocytes (PMNLs) and thereby abolishes its chemotactic properties.
- Belongs to peptidase family S8A.
|
| Cross-references |
|---|
| PROSITE | PDOC00125 |
| BRENDA | 3.4.21.110 |
| EC2PDB | 3.4.21.110 |
| ExplorEnz | 3.4.21.110 |
| PRIAM enzyme-specific profiles | 3.4.21.110 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.110 |
| IUBMB Enzyme Nomenclature | 3.4.21.110 |
| IntEnz | 3.4.21.110 |
| MEDLINE | Find literature relating to 3.4.21.110 |
| MetaCyc | 3.4.21.110 |
| UniProtKB/Swiss-Prot |
|
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