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ENZYME entry: EC 3.4.21.110

Accepted Name
C5a peptidase.
Alternative Name(s)
SCP.
Streptococcal C5a peptidase.
Reaction catalysed
The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59
Comment(s)
  • Surface-associated subtilisin-like serine peptidase with very specific substrate specificity.
  • Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a.
  • Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties.
  • Belongs to peptidase family S8A.
Cross-references
PROSITEPDOC00125
BRENDA3.4.21.110
EC2PDB3.4.21.110
ExplorEnz3.4.21.110
PRIAM enzyme-specific profiles3.4.21.110
KEGG Ligand Database for Enzyme Nomenclature3.4.21.110
IUBMB Enzyme Nomenclature3.4.21.110
IntEnz3.4.21.110
MEDLINEFind literature relating to 3.4.21.110
MetaCyc3.4.21.110
UniProtKB/Swiss-Prot
P58099, C5AP_STRP1;  P0DD34, C5AP_STRP3;  Q5X9R0, C5AP_STRP6;  
Q8NZ80, C5AP_STRP8;  P0DD35, C5AP_STRPQ;  P15926, C5AP_STRPY;  

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