To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...] View this page in https
ENZYME entry: EC 184.108.40.206
View entry in original ENZYME format
View entry in raw text format (no links)
in this entry
|Streptococcal C5a peptidase.|
|The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59|
- Surface-associated subtilisin-like serine peptidase with very
specific substrate specificity.
- Virulent strains of streptococci, including Streptococcus pyogenes,
can evade human detection and phagocytosis by destroying the
complement chemotaxin C5a.
- Cleavage of human C5a by this enzyme reduces the ability of C5a to
bind receptors on the surface of polymorphonuclear neutrophil
leukocytes (PMNLs) and thereby abolishes its chemotactic properties.
- Belongs to peptidase family S8A.
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
, with possibility to download in different formats, align etc.
entries corresponding to 3.4.21.-
entries corresponding to 3.4.-.-
entries corresponding to 3.-.-.-