ENZYME entry: EC 3.4.21.111

Accepted Name
Aqualysin 1.
Alternative Name(s)
Caldolysin.
Reaction catalysed
Exhibits low specificity toward esters of amino acids with small hydrophobic or aromatic residues at the P1 position
Comment(s)
  • This enzyme from the extreme thermophile, Thermus aquaticus, is an alkaline serine peptidase.
  • It has three subsites, S1, S2, and S3, in the substrate binding site.
  • The preferred amino acids at the S1 site are Ala and Phe, at the S2 site are Ala and norleucine and at the S3 site are Phe and Ile.
  • These specificities are similar to those of EC 3.4.21.62 and EC 3.4.21.64.
  • The enzyme displays broad specificity for cleavage of insulin B-chain and hydrolyzes elastin substrates such as succinyl-(Ala)(n)-p- nitroanilide (n = 1,2,3) and some peptide esters.
  • Belongs to peptidase family S8A.
Cross-references
PROSITEPDOC00125
BRENDA3.4.21.111
EC2PDB3.4.21.111
ExplorEnz3.4.21.111
PRIAM enzyme-specific profiles3.4.21.111
KEGG Ligand Database for Enzyme Nomenclature3.4.21.111
IUBMB Enzyme Nomenclature3.4.21.111
IntEnz3.4.21.111
MEDLINEFind literature relating to 3.4.21.111
MetaCyc3.4.21.111
UniProtKB/Swiss-Prot
P08594, AQL1_THEAQ

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