ENZYME entry: EC 3.4.21.115

Accepted Name
Infectious pancreatic necrosis birnavirus Vp4 peptidase.
Alternative Name(s)
Infectious pancreatic necrosis virus protease.
IPNV Vp4 peptidase.
IPNV Vp4 protease.
NS protease.
NS-associated protease.
Vp4 protease.
Reaction catalysed
Cleaves the (Ser/Thr)-Xaa-Ala-|-(Ser/Ala)-Gly motif in the polyprotein NH(2)-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions
Comment(s)
  • Infectious pancreatic necrosis virus (IPNV) is a birnavirus that causes an acute, contagious disease in young salmonid fish.
  • As with most viruses that infect eukaryotic cells, the proteolytic processing of viral precursor proteins is a crucial step in the life cycle of this virus.
  • pVP2 is converted into VP2 by cleavage near the carboxy end of pVP2; this cleavage is most likely due to host-cell proteases rather than VP4.
  • Differs from most serine peptidases in not having the catalytic triad Ser-His-Asp.
  • Belongs to peptidase family S50.
Cross-references
BRENDA3.4.21.115
EC2PDB3.4.21.115
ExplorEnz3.4.21.115
PRIAM enzyme-specific profiles3.4.21.115
KEGG Ligand Database for Enzyme Nomenclature3.4.21.115
IUBMB Enzyme Nomenclature3.4.21.115
IntEnz3.4.21.115
MEDLINEFind literature relating to 3.4.21.115
MetaCyc3.4.21.115

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