ENZYME entry: EC 3.4.22.68

Accepted Name
Ulp1 peptidase.
Alternative Name(s)
Smt3-protein conjugate proteinase.
Ubl-specific protease 1.
Ulp1.
Ulp1 endopeptidase.
Ulp1 protease.
Reaction catalysed
Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein
Comment(s)
  • The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation (epsilon-linked peptide bonds) reactions.
  • Ulp1 has several functions, including an essential role in chromosomal segregation and progression of the cell cycle through the G2/M phase of the cell cycle.
  • Belongs to peptidase family C48.
Cross-references
PROSITEPDOC50600
BRENDA3.4.22.68
EC2PDB3.4.22.68
ExplorEnz3.4.22.68
PRIAM enzyme-specific profiles3.4.22.68
KEGG Ligand Database for Enzyme Nomenclature3.4.22.68
IUBMB Enzyme Nomenclature3.4.22.68
IntEnz3.4.22.68
MEDLINEFind literature relating to 3.4.22.68
MetaCyc3.4.22.68
UniProtKB/Swiss-Prot
Q94F30, ESD4_ARATH;  Q9LSS7, RUBP1_ARATH;  Q9P0U3, SENP1_HUMAN;  
P59110, SENP1_MOUSE;  Q5RBB1, SENP1_PONAB;  Q9HC62, SENP2_HUMAN;  
Q91ZX6, SENP2_MOUSE;  Q5R7K7, SENP2_PONAB;  Q9EQE1, SENP2_RAT;  
Q9H4L4, SENP3_HUMAN;  Q9EP97, SENP3_MOUSE;  Q96HI0, SENP5_HUMAN;  
Q8WP32, SENP5_MACFA;  Q6NXL6, SENP5_MOUSE;  Q9GZR1, SENP6_HUMAN;  
Q6P7W0, SENP6_MOUSE;  A7MBJ2, SENP7_BOVIN;  Q9BQF6, SENP7_HUMAN;  
Q8BUH8, SENP7_MOUSE;  Q54XR2, SENP8_DICDI;  Q96LD8, SENP8_HUMAN;  
Q9D2Z4, SENP8_MOUSE;  Q5FVJ8, SENP8_RAT;  Q09353, SENP_CAEEL;  
Q8GYL3, ULP1A_ARATH;  O65278, ULP1B_ARATH;  Q8RWN0, ULP1C_ARATH;  
Q2PS26, ULP1D_ARATH;  O42957, ULP1_SCHPO;  Q02724, ULP1_YEAST;  
Q0WKV8, ULP2A_ARATH;  Q8L7S0, ULP2B_ARATH;  O13769, ULP2_SCHPO;  
P40537, ULP2_YEAST;  

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