ENZYME entry: EC 3.4.22.68
| Accepted Name |
|---|
| Ulp1 peptidase.
|
| Alternative Name(s) |
|---|
| Smt3-protein conjugate proteinase. |
| Ubl-specific protease 1. |
| Ulp1. |
| Ulp1 endopeptidase. |
| Ulp1 protease. |
| Reaction catalysed |
|---|
| Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein |
| Comment(s) |
|---|
- The enzyme from Saccharomyces cerevisiae can also recognize small
ubiquitin-like modifier 1 (SUMO-1) from human as a substrate in both
SUMO-processing (alpha-linked peptide bonds) and SUMO-deconjugation
(epsilon-linked peptide bonds) reactions.
- Ulp1 has several functions, including an essential role in
chromosomal segregation and progression of the cell cycle through the
G2/M phase of the cell cycle.
- Belongs to peptidase family C48.
|
| Cross-references |
|---|
| PROSITE | PDOC50600 |
| BRENDA | 3.4.22.68 |
| EC2PDB | 3.4.22.68 |
| ExplorEnz | 3.4.22.68 |
| PRIAM enzyme-specific profiles | 3.4.22.68 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.22.68 |
| IUBMB Enzyme Nomenclature | 3.4.22.68 |
| IntEnz | 3.4.22.68 |
| MEDLINE | Find literature relating to 3.4.22.68 |
| MetaCyc | 3.4.22.68 |
| UniProtKB/Swiss-Prot |
| Q94F30, ESD4_ARATH; | Q9LSS7, RUBP1_ARATH; | Q9P0U3, SENP1_HUMAN; |
| P59110, SENP1_MOUSE; | Q5RBB1, SENP1_PONAB; | Q9HC62, SENP2_HUMAN; |
| Q91ZX6, SENP2_MOUSE; | Q5R7K7, SENP2_PONAB; | Q9EQE1, SENP2_RAT; |
| Q9H4L4, SENP3_HUMAN; | Q9EP97, SENP3_MOUSE; | Q96HI0, SENP5_HUMAN; |
| Q8WP32, SENP5_MACFA; | Q6NXL6, SENP5_MOUSE; | Q9GZR1, SENP6_HUMAN; |
| Q6P7W0, SENP6_MOUSE; | A7MBJ2, SENP7_BOVIN; | Q9BQF6, SENP7_HUMAN; |
| Q8BUH8, SENP7_MOUSE; | Q54XR2, SENP8_DICDI; | Q96LD8, SENP8_HUMAN; |
| Q9D2Z4, SENP8_MOUSE; | Q5FVJ8, SENP8_RAT; | Q09353, SENP_CAEEL; |
| Q8GYL3, ULP1A_ARATH; | O65278, ULP1B_ARATH; | Q8RWN0, ULP1C_ARATH; |
| Q2PS26, ULP1D_ARATH; | O42957, ULP1_SCHPO; | Q02724, ULP1_YEAST; |
| Q0WKV8, ULP2A_ARATH; | Q8L7S0, ULP2B_ARATH; | O13769, ULP2_SCHPO; |
| P40537, ULP2_YEAST; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.22.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-