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ENZYME entry: EC 3.4.23.1

Accepted Name
Pepsin A.
Alternative Name(s)
Pepsin.
Reaction catalysed
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin
Comment(s)
  • The predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.1.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.1
EC2PDB3.4.23.1
ExplorEnz3.4.23.1
PRIAM enzyme-specific profiles3.4.23.1
KEGG Ligand Database for Enzyme Nomenclature3.4.23.1
IUBMB Enzyme Nomenclature3.4.23.1
IntEnz3.4.23.1
MEDLINEFind literature relating to 3.4.23.1
MetaCyc3.4.23.1
UniProtKB/Swiss-Prot
P03954, PEPA1_MACFU;  P28712, PEPA1_RABIT;  P27677, PEPA2_MACFU;  
P27821, PEPA2_RABIT;  P0DJD8, PEPA3_HUMAN;  P27822, PEPA3_RABIT;  
P0DJD7, PEPA4_HUMAN;  P27678, PEPA4_MACFU;  P28713, PEPA4_RABIT;  
P0DJD9, PEPA5_HUMAN;  P27823, PEPAF_RABIT;  P00792, PEPA_BOVIN;  
Q9N2D4, PEPA_CALJA;  Q9GMY6, PEPA_CANFA;  P00793, PEPA_CHICK;  
P11489, PEPA_MACMU;  P00791, PEPA_PIG;  Q9GMY7, PEPA_RHIFE;  
Q9GMY8, PEPA_SORUN;  P81497, PEPA_SUNMU;  P13636, PEPA_URSTH;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.23.-
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