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ENZYME

ENZYME entry: EC 3.4.23.20

Accepted Name
penicillopepsin
Alternative Name(s)
Penicillium janthinellum aspartic protease
peptidase A
Reaction catalysed
Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen
Comment(s)
  • From the imperfect fungus Penicillium janthinellum.
  • Closely related enzymes have been isolated from P.roqueforti and P.duponti.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.7.
Cross-references
BRENDA3.4.23.20
EC2PDB3.4.23.20
ExplorEnz3.4.23.20
PRIAM enzyme-specific profiles3.4.23.20
KEGG Ligand Database for Enzyme Nomenclature3.4.23.20
IUBMB Enzyme Nomenclature3.4.23.20
IntEnz3.4.23.20
MEDLINEFind literature relating to 3.4.23.20
MetaCyc3.4.23.20
Rhea expert-curated reactions3.4.23.20
UniProtKB/Swiss-Prot
P00798, PEPA1_PENJAP78735, PEPA2_PENJAQ9HEZ3, PEPA3_PENJA
Q01972, PEPA_PENROB6HL60, PEPA_PENRWB8MF81, PEPA_TALSN

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