ENZYME entry: EC 3.4.23.24

Accepted Name
Candidapepsin.
Alternative Name(s)
Candida albicans aspartic proteinase.
Reaction catalysed
Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin
Comment(s)
  • This endopeptidase from the imperfect yeast Candida albicans is inhibited by pepstatin, but not by methyl 2-diazoacetamido-hexanoate or 1,2-epoxy-3-(p-nitrophenoxy)propane.
  • Belongs to peptidase family A1.
  • Formerly EC 3.4.4.17 and EC 3.4.23.6.
Cross-references
PROSITEPDOC00128
BRENDA3.4.23.24
EC2PDB3.4.23.24
ExplorEnz3.4.23.24
PRIAM enzyme-specific profiles3.4.23.24
KEGG Ligand Database for Enzyme Nomenclature3.4.23.24
IUBMB Enzyme Nomenclature3.4.23.24
IntEnz3.4.23.24
MEDLINEFind literature relating to 3.4.23.24
MetaCyc3.4.23.24
UniProtKB/Swiss-Prot
Q5A651, CAR10_CANAL;  P0CY27, CARP1_CANAL;  C4YSF6, CARP1_CANAW;  
P0CY26, CARP1_CANAX;  P32951, CARP1_CANPA;  P0DJ06, CARP2_CANAL;  
C4YMJ3, CARP2_CANAW;  P0CS83, CARP2_CANAX;  P32950, CARP2_CANPA;  
P0CY29, CARP3_CANAL;  C4YNQ5, CARP3_CANAW;  P0CY28, CARP3_CANAX;  
Q5A8N2, CARP4_CANAL;  P43093, CARP4_CANAW;  P43094, CARP5_CANAL;  
Q5AC08, CARP6_CANAL;  P43095, CARP6_CANAX;  Q59VH7, CARP7_CANAL;  
P43096, CARP7_CANAX;  Q5AEM6, CARP8_CANAL;  O42778, CARP8_CANAX;  
Q59SU1, CARP9_CANAL;  O42779, CARP9_CANAX;  Q00663, CARP_CANTR;  

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