ENZYME entry: EC 3.4.23.3
| Accepted Name |
|---|
| Gastricsin.
|
| Alternative Name(s) |
|---|
| Pepsin C. |
| Reaction catalysed |
|---|
| More restricted specificity than pepsin A, but shows preferential cleavage at Tyr-|-Xaa bonds. High activity on hemoglobin |
| Comment(s) |
|---|
- Formed from progastricsin, apparently in the gastric juice of most
vertebrates.
- In addition to the fundus, progastricsin is also secreted in antrum
and proximal duodenum.
- Seminal plasma contains a zymogen that is immunologically identical
with progastricsin.
- Belongs to peptidase family A1.
- Formerly EC 3.4.4.22.
|
| Cross-references |
|---|
| PROSITE | PDOC00128 |
| BRENDA | 3.4.23.3 |
| EC2PDB | 3.4.23.3 |
| ExplorEnz | 3.4.23.3 |
| PRIAM enzyme-specific profiles | 3.4.23.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.23.3 |
| IUBMB Enzyme Nomenclature | 3.4.23.3 |
| IntEnz | 3.4.23.3 |
| MEDLINE | Find literature relating to 3.4.23.3 |
| MetaCyc | 3.4.23.3 |
| UniProtKB/Swiss-Prot |
| Q9N2D3, PEPC_CALJA; | Q64411, PEPC_CAVPO; | P20142, PEPC_HUMAN; |
| P03955, PEPC_MACFU; | Q689Z7, PEPC_MONDO; | Q9D7R7, PEPC_MOUSE; |
| P30879, PEPC_PIG; | Q9GMY2, PEPC_RABIT; | P04073, PEPC_RAT; |
| Q9GMY3, PEPC_RHIFE; | Q9GMY4, PEPC_SORUN; | P81498, PEPC_SUNMU; |
|
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